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This is the development version of AnnotationHub; for the stable release version, see AnnotationHub.

Client to access AnnotationHub resources

Bioconductor version: Development (3.20)

This package provides a client for the Bioconductor AnnotationHub web resource. The AnnotationHub web resource provides a central location where genomic files (e.g., VCF, bed, wig) and other resources from standard locations (e.g., UCSC, Ensembl) can be discovered. The resource includes metadata about each resource, e.g., a textual description, tags, and date of modification. The client creates and manages a local cache of files retrieved by the user, helping with quick and reproducible access.

Author: Bioconductor Package Maintainer [cre], Martin Morgan [aut], Marc Carlson [ctb], Dan Tenenbaum [ctb], Sonali Arora [ctb], Valerie Oberchain [ctb], Kayla Morrell [ctb], Lori Shepherd [aut]

Maintainer: Bioconductor Package Maintainer <maintainer at>

Citation (from within R, enter citation("AnnotationHub")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

AnnotationHub: Access the AnnotationHub Web Service HTML R Script
AnnotationHub: AnnotationHub HOW TO's HTML R Script
Troubleshooting The Hubs HTML R Script
Reference Manual PDF


biocViews DataImport, GUI, Infrastructure, Software, ThirdPartyClient
Version 3.13.0
In Bioconductor since BioC 2.12 (R-3.0) (11 years)
License Artistic-2.0
Depends BiocGenerics(>= 0.15.10), BiocFileCache(>= 1.5.1)
Imports utils, methods, grDevices, RSQLite, BiocManager, BiocVersion, curl, rappdirs, AnnotationDbi(>= 1.31.19), S4Vectors, httr, yaml, dplyr
System Requirements
Bug Reports
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Suggests IRanges, GenomicRanges, GenomeInfoDb, VariantAnnotation, Rsamtools, rtracklayer, BiocStyle, knitr, AnnotationForge, rBiopaxParser, RUnit, txdbmaker, MSnbase, mzR, Biostrings, CompoundDb, keras, ensembldb, SummarizedExperiment, ExperimentHub, gdsfmt, rmarkdown, HubPub
Linking To
Enhances AnnotationHubData
Depends On Me adductomicsR, AnnotationHubData, ExperimentHub, hipathia, ipdDb, LRcell, octad, AlphaMissense.v2023.hg19, AlphaMissense.v2023.hg38, cadd.v1.6.hg19, cadd.v1.6.hg38, EpiTxDb.Hs.hg38, EpiTxDb.Mm.mm10, EpiTxDb.Sc.sacCer3, EuPathDB, GenomicState, org.Mxanthus.db, phastCons30way.UCSC.hg38, phastCons35way.UCSC.mm39, phyloP35way.UCSC.mm39, rGenomeTracksData,, UCSCRepeatMasker, MetaGxBreast, MetaGxOvarian, NestLink, scMultiome, sesameData, tartare, annotation, sequencing, OSCA.basic, OSCA.workflows
Imports Me annotatr, atena, BiocHubsShiny, circRNAprofiler, coMethDMR, cTRAP, customCMPdb, DMRcate, dmrseq, EpiMix, epimutacions, epiregulon, gDNAx, GenomicScores, GRaNIE, GSEABenchmarkeR, gwascat, iSEEhub, MACSr, meshes, MetaboAnnotation, MethReg, Moonlight2R, MSnID, OGRE, orthos, partCNV, psichomics, regutools, REMP, scanMiRApp, scAnnotatR, scmeth, scTensor, singleCellTK, SpliceWiz, tximeta, Ularcirc, AHLRBaseDbs, AHMeSHDbs, AHPathbankDbs, AHPubMedDbs, AHWikipathwaysDbs, alternativeSplicingEvents.hg19, alternativeSplicingEvents.hg38, EPICv2manifest, grasp2db, HPO.db, metaboliteIDmapping, MPO.db, synaptome.db, adductData, BioImageDbs, biscuiteerData, celldex, chipseqDBData, crisprScoreData, curatedMetagenomicData, curatedPCaData, curatedTBData, curatedTCGAData, depmap, DropletTestFiles, easierData, FieldEffectCrc, FlowSorted.Blood.EPIC, FlowSorted.CordBloodCombined.450k, GenomicDistributionsData, HCAData, HiBED, HiContactsData, HMP16SData, HMP2Data, mcsurvdata, MerfishData, MetaGxPancreas, MouseAgingData, msigdb, orthosData, scpdata, scRNAseq, SFEData, SingleCellMultiModal, spatialLIBD, TabulaMurisSenisData, TENxBrainData, TENxBUSData, TENxPBMCData, tuberculosis, TCGAWorkflow, RNAseqQC, SeedMatchR
Suggests Me AHMassBank, AlphaMissenseR, autonomics, Chicago, ChIPpeakAnno, CINdex, clusterProfiler, CNVRanger, COCOA, crisprViz, DNAshapeR, dupRadar, ELMER, ensembldb, epiNEM, EpiTxDb, epivizrChart, epivizrData, factR, GenomicRanges, Glimma, GOSemSim, HiCool, LRBaseDbi, lute, maser, methodical, MIRA, motifTestR, MSnbase, multicrispr, nullranges, OrganismDbi, plotgardener, raer, recountmethylation, satuRn, scTensor, simona, TCGAbiolinks, TCGAutils, tidyCoverage, VariantAnnotation, xcore, AHEnsDbs, CTCF, ENCODExplorerData, excluderanges, gwascatData, ontoProcData, BioPlex, HarmonizedTCGAData, homosapienDEE2CellScore, GeneSelectR, locuszoomr
Links To Me
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Follow Installation instructions to use this package in your R session.

Source Package AnnotationHub_3.13.0.tar.gz
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macOS Binary (x86_64) AnnotationHub_3.13.0.tgz
macOS Binary (arm64) AnnotationHub_3.13.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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