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This is the development version of epiNEM; for the stable release version, see epiNEM.


Bioconductor version: Development (3.20)

epiNEM is an extension of the original Nested Effects Models (NEM). EpiNEM is able to take into account double knockouts and infer more complex network signalling pathways. It is tailored towards large scale double knock-out screens.

Author: Madeline Diekmann & Martin Pirkl

Maintainer: Martin Pirkl <martinpirkl at>

Citation (from within R, enter citation("epiNEM")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

epiNEM HTML R Script
Reference Manual PDF


biocViews Network, NetworkInference, Pathways, Software, SystemsBiology
Version 1.29.0
In Bioconductor since BioC 3.5 (R-3.4) (7 years)
License GPL-3
Depends R (>= 4.1)
Imports BoolNet, e1071, gtools, stats, igraph, utils, lattice, latticeExtra, RColorBrewer, pcalg, minet, grDevices, graph, mnem, latex2exp
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Suggests knitr, RUnit, BiocGenerics, STRINGdb, devtools, rmarkdown, GOSemSim, AnnotationHub, org.Sc.sgd.db, BiocStyle
Linking To
Depends On Me
Imports Me bnem, dce, nempi
Suggests Me mnem
Links To Me
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Follow Installation instructions to use this package in your R session.

Source Package epiNEM_1.29.0.tar.gz
Windows Binary (64-bit only)
macOS Binary (x86_64) epiNEM_1.29.0.tgz
macOS Binary (arm64) epiNEM_1.29.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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