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This is the development version of octad; for the stable release version, see octad.

Open Cancer TherApeutic Discovery (OCTAD)

Bioconductor version: Development (3.20)

OCTAD provides a platform for virtually screening compounds targeting precise cancer patient groups. The essential idea is to identify drugs that reverse the gene expression signature of disease by tamping down over-expressed genes and stimulating weakly expressed ones. The package offers deep-learning based reference tissue selection, disease gene expression signature creation, pathway enrichment analysis, drug reversal potency scoring, cancer cell line selection, drug enrichment analysis and in silico hit validation. It currently covers ~20,000 patient tissue samples covering 50 cancer types, and expression profiles for ~12,000 distinct compounds.

Author: E. Chekalin [aut, cre], S. Paithankar [aut], B. Zeng [aut], B. Glicksberg [ctb], P. Newbury [ctb], J. Xing [ctb], K. Liu [ctb], A. Wen [ctb], D. Joseph [ctb], B. Chen [aut]

Maintainer: E. Chekalin <eygen.chekalin at>

Citation (from within R, enter citation("octad")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

octad HTML R Script
Reference Manual PDF


biocViews Classification, GeneExpression, GeneSetEnrichment, Pharmacogenetics, Pharmacogenomics, Software
Version 1.7.0
In Bioconductor since BioC 3.16 (R-4.2) (1.5 years)
License Artistic-2.0
Depends R (>= 4.2.0), magrittr, dplyr, ggplot2, edgeR, RUVSeq, DESeq2, limma, rhdf5, foreach, Rfast, octad.db, stats, httr, qpdf, ExperimentHub, AnnotationHub, Biobase, S4Vectors
Imports EDASeq, GSVA, data.table, htmlwidgets, plotly, reshape2, grDevices, utils
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Suggests knitr, rmarkdown
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Follow Installation instructions to use this package in your R session.

Source Package octad_1.7.0.tar.gz
Windows Binary
macOS Binary (x86_64) octad_1.7.0.tgz
macOS Binary (arm64) octad_1.7.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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