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This is the development version of dorothea; for the stable release version, see dorothea.

Collection Of Human And Mouse TF Regulons

Bioconductor version: Development (3.20)

DoRothEA is a gene regulatory network containing signed transcription factor (TF) - target gene interactions. DoRothEA regulons, the collection of a TF and its transcriptional targets, were curated and collected from different types of evidence for both human and mouse. A confidence level was assigned to each TF-target interaction based on the number of supporting evidence.

Author: Pau Badia-i-Mompel [cre] , Daniel Dimitrov [aut] , Christian H. Holland [aut] , Luz Garcia-Alonso [aut], Alberto Valdeolivas [ctb], Minoo Ashtiani [ctb], Attila Gabor [ctb]

Maintainer: Pau Badia-i-Mompel <pau.badia at>

Citation (from within R, enter citation("dorothea")):


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DoRothEA regulons. HTML R Script
Reference Manual PDF


biocViews ExperimentData, Homo_sapiens_Data, Mus_musculus_Data
Version 1.15.1
License GPL-3 + file LICENSE
Depends R (>= 4.0)
Imports dplyr, magrittr, bcellViper, decoupleR
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Suggests Biobase, BiocStyle, OmnipathR, viper, knitr, pheatmap, pkgdown, rmarkdown, Seurat, SingleCellExperiment, SummarizedExperiment, testthat (>= 2.1.0), tibble, tidyr, utils
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Imports Me cosmosR, easier
Suggests Me epiregulon.extra, MethReg
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