Registration Open for Bioc2024 July 24-26


This is the development version of trio; for the stable release version, see trio.

Testing of SNPs and SNP Interactions in Case-Parent Trio Studies

Bioconductor version: Development (3.20)

Testing SNPs and SNP interactions with a genotypic TDT. This package furthermore contains functions for computing pairwise values of LD measures and for identifying LD blocks, as well as functions for setting up matched case pseudo-control genotype data for case-parent trios in order to run trio logic regression, for imputing missing genotypes in trios, for simulating case-parent trios with disease risk dependent on SNP interaction, and for power and sample size calculation in trio data.

Author: Holger Schwender, Qing Li, Philipp Berger, Christoph Neumann, Margaret Taub, Ingo Ruczinski

Maintainer: Holger Schwender <holger.schw at>

Citation (from within R, enter citation("trio")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Trio Logic Regression and genotypic TDT PDF R Script
Reference Manual PDF


biocViews GeneticVariability, Genetics, Microarray, SNP, Software
Version 3.43.0
In Bioconductor since BioC 2.13 (R-3.0) (11 years)
License LGPL-2
Depends R (>= 3.0.1)
Imports grDevices, graphics, methods, stats, survival, utils, siggenes, LogicReg (>= 1.6.1)
System Requirements
See More
Suggests haplo.stats, mcbiopi, splines, logicFS(>= 1.28.1), KernSmooth, VariantAnnotation
Linking To
Depends On Me
Imports Me
Suggests Me
Links To Me
Build Report Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package trio_3.43.0.tar.gz
Windows Binary
macOS Binary (x86_64) trio_3.43.0.tgz
macOS Binary (arm64) trio_3.43.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
Bioc Package Browser
Package Short Url
Package Downloads Report Download Stats