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This is the development version of YAPSA; for the stable release version, see YAPSA.

Yet Another Package for Signature Analysis

Bioconductor version: Development (3.20)

This package provides functions and routines for supervised analyses of mutational signatures (i.e., the signatures have to be known, cf. L. Alexandrov et al., Nature 2013 and L. Alexandrov et al., Bioaxiv 2018). In particular, the family of functions LCD (LCD = linear combination decomposition) can use optimal signature-specific cutoffs which takes care of different detectability of the different signatures. Moreover, the package provides different sets of mutational signatures, including the COSMIC and PCAWG SNV signatures and the PCAWG Indel signatures; the latter infering that with YAPSA, the concept of supervised analysis of mutational signatures is extended to Indel signatures. YAPSA also provides confidence intervals as computed by profile likelihoods and can perform signature analysis on a stratified mutational catalogue (SMC = stratify mutational catalogue) in order to analyze enrichment and depletion patterns for the signatures in different strata.

Author: Daniel Huebschmann [aut], Lea Jopp-Saile [aut], Carolin Andresen [aut], Zuguang Gu [aut, cre], Matthias Schlesner [aut]

Maintainer: Zuguang Gu < at>

Citation (from within R, enter citation("YAPSA")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

1. Usage of YAPSA HTML R Script
2. Signature-specific cutoffs HTML R Script
3. Confidence Intervals HTML R Script
4. Stratified Analysis of Mutational Signatures HTML R Script
5. Indel signature analysis HTML R Script
6. Usage of YAPSA for WES data HTML R Script
Reference Manual PDF


biocViews BiologicalQuestion, Clustering, DNASeq, GenomicVariation, Sequencing, Software, SomaticMutation, StatisticalMethod, Visualization
Version 1.31.0
In Bioconductor since BioC 3.4 (R-3.3) (7.5 years)
License GPL-3
Depends R (>= 4.0.0), GenomicRanges, ggplot2, grid
Imports limSolve, SomaticSignatures, VariantAnnotation, GenomeInfoDb, reshape2, gridExtra, corrplot, dendextend, GetoptLong, circlize, gtrellis, doParallel, parallel, PMCMRplus, ggbeeswarm, ComplexHeatmap, KEGGREST, grDevices, Biostrings, BSgenome.Hsapiens.UCSC.hg19, magrittr, pracma, dplyr, utils
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Suggests testthat, BiocStyle, knitr, rmarkdown
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Follow Installation instructions to use this package in your R session.

Source Package YAPSA_1.31.0.tar.gz
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macOS Binary (x86_64) YAPSA_1.31.0.tgz
macOS Binary (arm64) YAPSA_1.31.0.tgz
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Source Repository (Developer Access) git clone
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