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This is the development version of TPP2D; for the stable release version, see TPP2D.

Detection of ligand-protein interactions from 2D thermal profiles (DLPTP)

Bioconductor version: Development (3.20)

Detection of ligand-protein interactions from 2D thermal profiles (DLPTP), Performs an FDR-controlled analysis of 2D-TPP experiments by functional analysis of dose-response curves across temperatures.

Author: Nils Kurzawa [aut, cre], Holger Franken [aut], Simon Anders [aut], Wolfgang Huber [aut], Mikhail M. Savitski [aut]

Maintainer: Nils Kurzawa <nilskurzawa at>

Citation (from within R, enter citation("TPP2D")):


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if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


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To view documentation for the version of this package installed in your system, start R and enter:

Introduction to TPP2D for 2D-TPP analysis HTML R Script
Reference Manual PDF


biocViews DataImport, Proteomics, Software
Version 1.21.0
In Bioconductor since BioC 3.9 (R-3.6) (5 years)
License GPL-3
Depends R (>= 3.6.0), stats, utils, dplyr, methods
Imports ggplot2, tidyr, foreach, doParallel, openxlsx, stringr, RCurl, parallel, MASS, BiocParallel, limma
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Source Package TPP2D_1.21.0.tar.gz
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