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Affymetrix Spike-in Langmuir Isotherm Data Analysis Tool

Bioconductor version: Release (3.19)

SpikeLI is a package that performs the analysis of the Affymetrix spike-in data using the Langmuir Isotherm. The aim of this package is to show the advantages of a physical-chemistry based analysis of the Affymetrix microarray data compared to the traditional methods. The spike-in (or Latin square) data for the HGU95 and HGU133 chipsets have been downloaded from the Affymetrix web site. The model used in the spikeLI package is described in details in E. Carlon and T. Heim, Physica A 362, 433 (2006).

Author: Delphine Baillon, Paul Leclercq <paulleclercq at>, Sarah Ternisien, Thomas Heim, Enrico Carlon <enrico.carlon at>

Maintainer: Enrico Carlon <enrico.carlon at>

Citation (from within R, enter citation("spikeLI")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

spikeLI PDF
Reference Manual PDF


biocViews Microarray, QualityControl, Software
Version 2.64.0
In Bioconductor since BioC 1.9 (R-2.4) (18 years)
License GPL-2
Imports graphics, grDevices, stats, utils
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Follow Installation instructions to use this package in your R session.

Source Package spikeLI_2.64.0.tar.gz
Windows Binary (64-bit only)
macOS Binary (x86_64) spikeLI_2.64.0.tgz
macOS Binary (arm64) spikeLI_2.64.0.tgz
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Source Repository (Developer Access) git clone
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