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Analysis and quantitation of isobarically tagged MSMS proteomics data

Bioconductor version: Release (3.19)

isobar provides methods for preprocessing, normalization, and report generation for the analysis of quantitative mass spectrometry proteomics data labeled with isobaric tags, such as iTRAQ and TMT. Features modules for integrating and validating PTM-centric datasets (isobar-PTM). More information on

Author: Florian P Breitwieser < at> and Jacques Colinge <jacques.colinge at>, with contributions from Alexey Stukalov <stukalov at>, Xavier Robin <xavier.robin at> and Florent Gluck <florent.gluck at>

Maintainer: Florian P Breitwieser < at>

Citation (from within R, enter citation("isobar")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

isobar for developers PDF R Script
isobar for quantification of PTM datasets PDF R Script
isobar package for iTRAQ and TMT protein quantification PDF R Script
Usecases for isobar package PDF R Script
Reference Manual PDF


biocViews Bioinformatics, ImmunoOncology, MassSpectrometry, MultipleComparisons, Proteomics, QualityControl, Software
Version 1.50.0
In Bioconductor since BioC 2.9 (R-2.14) (12.5 years)
License LGPL-2
Depends R (>= 2.10.0), Biobase, stats, methods
Imports distr, plyr, biomaRt, ggplot2
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Suggests MSnbase, OrgMassSpecR, XML, RJSONIO, Hmisc, gplots, RColorBrewer, gridExtra, limma, boot, DBI, MASS
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Follow Installation instructions to use this package in your R session.

Source Package isobar_1.50.0.tar.gz
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macOS Binary (x86_64) isobar_1.50.0.tgz
macOS Binary (arm64) isobar_1.50.0.tgz
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Source Repository (Developer Access) git clone
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