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Gene-Specific Phenotype EstimatoR

Bioconductor version: Release (3.19)

Estimates gene-specific phenotypes from off-target confounded RNAi screens. The phenotype of each siRNA is modeled based on on-targeted and off-targeted genes, using a regularized linear regression model.

Author: Fabian Schmich

Maintainer: Fabian Schmich <fabian.schmich at>

Citation (from within R, enter citation("gespeR")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

An R package for deconvoluting off-target confounded RNAi screens PDF R Script
Reference Manual PDF


biocViews CellBasedAssays, GeneTarget, ImmunoOncology, Preprocessing, Regression, Software, Visualization
Version 1.36.0
In Bioconductor since BioC 3.1 (R-3.2) (9.5 years)
License GPL-3
Depends methods, graphics, ggplot2, R (>= 2.10)
Imports Matrix, glmnet, cellHTS2, Biobase, biomaRt, doParallel, parallel, foreach, reshape2, dplyr
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Follow Installation instructions to use this package in your R session.

Source Package gespeR_1.36.0.tar.gz
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macOS Binary (x86_64) gespeR_1.36.0.tgz
macOS Binary (arm64) gespeR_1.36.0.tgz
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Source Repository (Developer Access) git clone
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