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Summix2: A suite of methods to estimate, adjust, and leverage substructure in genetic summary data

Bioconductor version: Release (3.19)

This package contains the Summix2 method for estimating and adjusting for substructure in genetic summary allele frequency data. The function summix() estimates reference group proportions using a mixture model. The adjAF() function produces adjusted allele frequencies for an observed group with reference group proportions matching a target individual or sample. The summix_local() function estimates local ancestry mixture proportions and performs selection scans in genetic summary data.

Author: Audrey Hendricks [cre], Price Adelle [aut], Stoneman Haley [aut]

Maintainer: Audrey Hendricks <audrey.hendricks at>

Citation (from within R, enter citation("Summix")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Summix.html HTML R Script
Reference Manual PDF


biocViews Genetics, Software, StatisticalMethod, WholeGenome
Version 2.10.0
In Bioconductor since BioC 3.13 (R-4.1) (3 years)
License MIT + file LICENSE
Depends R (>= 4.3)
Imports dplyr, nloptr, magrittr, methods, tibble, tidyselect, BEDASSLE, scales, visNetwork, randomcoloR
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Suggests rmarkdown, markdown, knitr, testthat (>= 3.0.0)
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Follow Installation instructions to use this package in your R session.

Source Package Summix_2.10.0.tar.gz
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macOS Binary (x86_64) Summix_2.10.0.tgz
macOS Binary (arm64) Summix_2.10.0.tgz
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