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Remove Unwanted Variation from RNA-Seq Data

Bioconductor version: Release (3.19)

This package implements the remove unwanted variation (RUV) methods of Risso et al. (2014) for the normalization of RNA-Seq read counts between samples.

Author: Davide Risso [aut, cre, cph], Sandrine Dudoit [aut], Lorena Pantano [ctb], Kamil Slowikowski [ctb]

Maintainer: Davide Risso <risso.davide at>

Citation (from within R, enter citation("RUVSeq")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

RUVSeq: Remove Unwanted Variation from RNA-Seq Data HTML R Script
Reference Manual PDF


biocViews DifferentialExpression, ImmunoOncology, Preprocessing, RNASeq, Software
Version 1.38.0
In Bioconductor since BioC 3.0 (R-3.1) (10 years)
License Artistic-2.0
Depends Biobase, EDASeq(>= 1.99.1), edgeR
Imports methods, MASS
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Suggests BiocStyle, knitr, RColorBrewer, zebrafishRNASeq, DESeq2
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Depends On Me octad, rnaseqGene
Imports Me consensusDE, ribosomeProfilingQC, scone, standR
Suggests Me DEScan2, NanoTube
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Follow Installation instructions to use this package in your R session.

Source Package RUVSeq_1.38.0.tar.gz
Windows Binary
macOS Binary (x86_64) RUVSeq_1.38.0.tgz
macOS Binary (arm64) RUVSeq_1.38.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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