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A Package for De Novo CNV Detection in Case-Parent Trios

Bioconductor version: Release (3.19)

Analysis of de novo copy number variants in trios from high-dimensional genotyping platforms.

Author: Robert B Scharpf and Ingo Ruczinski

Maintainer: Robert Scharpf <rscharpf at>

Citation (from within R, enter citation("MinimumDistance")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Detection of de novo copy number alterations in case-parent trios PDF R Script
Reference Manual PDF


biocViews CopyNumberVariation, Microarray, SNP, Software
Version 1.48.0
In Bioconductor since BioC 2.10 (R-2.15) (12.5 years)
License Artistic-2.0
Depends R (>= 3.5.0), VanillaICE(>= 1.47.1)
Imports methods, BiocGenerics, MatrixGenerics, Biobase, S4Vectors(>= 0.23.18), IRanges, GenomeInfoDb, GenomicRanges(>= 1.17.16), SummarizedExperiment(>= 1.15.4), oligoClasses, DNAcopy, ff, foreach, matrixStats, lattice, data.table, grid, stats, utils
System Requirements
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Suggests human610quadv1bCrlmm(>= 1.0.3), BSgenome.Hsapiens.UCSC.hg18, BSgenome.Hsapiens.UCSC.hg19, RUnit
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Enhances snow, doSNOW
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