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  MultiOmicsBridge Analysis Report
  Generated: 2026-05-12 22:09
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MODULE 1: Data Summary
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  Paired samples      : 879
  Latent components   : 2
  Integration method  : DIABLO
  Outcome             : nonIBD vs UC
  Host features used  : 52 per component
  MB features used    : 9 per component

MODULE 3: Multi-Omics Biomarkers
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  Total biomarkers    : 120 (60 host, 60 microbiome)
  Top 15 biomarkers (by loading score):
  Rank Feature                   Layer        Loading
     1 species:Alistipes putredinis microbiome   0.7707
     1 ENSG00023445              host         0.4747
     2 species:[Ruminococcus] torques microbiome   0.4543
     3 species:Firmicutes bacterium CAG:83 microbiome   0.4365
     4 species:Akkermansia muciniphila microbiome   0.4014
     5 species:Bacteroides uniformis microbiome   0.3712
     2 ENSG00009741              host         0.3647
     6 species:Roseburia hominis microbiome   0.3579
     7 species:Blautia obeum     microbiome   0.3514
     8 species:Hungatella hathewayi microbiome   0.3488
     9 species:Bacteroides ovatus microbiome   0.2978
    10 species:[Clostridium] symbiosum microbiome   0.2782
     3 ENSG00041724              host         0.2735
    11 species:Gemmiger formicilis microbiome   0.2582
     4 ENSG00014638              host         0.2577

  Top cross-omics hubs (highest partner correlation):
  species:[Clostridium] symbiosum -> CFTR                      (r=0.342)
  species:Alistipes putredinis -> CFTR                      (r=0.328)
  species:Bacteroides ovatus -> ATOH1                     (r=0.286)
  species:Firmicutes bacterium CAG:83 -> CFTR                      (r=0.261)
  species:Gemmiger formicilis -> CLDN4                     (r=0.229)

MODULE 4: Diagnostic Classifier Performance
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  Cross-validation    : 5-fold
  Host RNA-seq only       AUC = 1.000 +/- 0.000
  Microbiome only         AUC = 0.981 +/- 0.011
  Joint (multi-omics)     AUC = 1.000 +/- 0.000

  Multi-omics gain vs host-only: +0.000 AUC

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  End of report
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