1 Abstract

Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.

If you have questions, please direct it to: Macarron Forum

2 Installation

Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:

if(!requireNamespace("BiocManager", quietly = TRUE))
    install.packages("BiocManager")
BiocManager::install("Macarron")

3 Running Macarron

Macarron can be run from the command line or as an R function. Both methods require the same arguments, have the same options, and use the same default settings. The package includes the wrapper Macarron() as well as functions which perform different steps in the Macarron framework.

3.1 Input CSV files

Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.

  1. Metabolic features abundances
    • Must contain features in rows and samples in columns.
    • First column must identify features.
  2. Metabolic features annotations
    • Must contain features in rows and annotations in columns.
    • First column must identify features.
    • Second column must contain either HMDB ID or PubChem Compound Identifier (CID).
    • Third column must contain the name of the metabolite.
    • Fourth column must contain a continuous chemical property such as m/z or RT or shift/ppm.
    • Other annotations such as RT, m/z or other identifiers can be listed column 4 onward.
  3. Sample metadata
    • Must contain samples in rows and metadata in columns.
    • First column must identify samples.
    • Second column must contain categorical metadata relevant to prioritization such as phenotypes, exposures or environments.
  4. Chemical taxonomy
    • First column must contain the HMDB ID or PubChem CID. IDs must be consistent between annotation and taxonomy files.
    • Second and third columns must contain chemical subclass and class of the respective metabolite.

If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID (see Advanced Topics).

3.2 Output Files

By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv. Another file, prioritized_metabolites_characterizable.csv is a subset of prioritized_metabolites_all.csv and only contains metabolic features which covary with at least one annotated metabolite. The columns in these output files are:

  • Feature_index: Lists the identifier of the metabolic feature found in column 1 of abundance and annotation files.
  • HMDB_ID (or PubChem ID): Public database identifier from column 2 of annotation file (column 1 of annotation dataframe).
  • Metabolite name: From column 2 of annotation dataframe.
  • mz: The continuous numerical chemical property from column 3 of the annotation dataframe.
  • Priority_score: 1 indicates most prioritized. It is the percentile from the meta-rank of AVA, q-value and effect size.
  • Status: Direction of perturbation (differential abundance) in the phenotype (or environment) of interest compared to reference phenotype.
  • Module: ID of the covariance module a metabolic feature is a member of. Module = 0 indicates a singleton i.e., a metabolic feature that is not assigned to any module.
  • Anchor (of a module): Metabolic feature that has the highest abundance in any phenotype.
  • Related_classes: Chemical taxonomy of the annotated features that covary with a metabolic feature.
  • Covaries_with_standard: 1 (yes) and 0 (no). Column specifies if the metabolic feature covaries with at least one annotated (standard) metabolite.
  • AVA: Abundance versus anchor which is a ratio of the highest abundance (in any phenotype) of a metabolic feature and highest abundance of the covarying anchor. Naturally, the AVA of an anchor metabolite is 1.
  • qvalue: Estimated from multivariate linear model using Maaslin2.
  • effect_size
  • Remaining columns from the annotation dataframe are appended.

3.3 Run a demo in R

3.3.1 Using CSV files as inputs

Example (demo) input files can be found under inst/extdata folder of the Macarron source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv, demo_annotations.csv, demo_metadata.csv, and demo_taxonomy.csv.

library(Macarron)
## Loading required package: SummarizedExperiment
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
## 
## Attaching package: 'MatrixGenerics'
## The following objects are masked from 'package:matrixStats':
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##     colAlls, colAnyNAs, colAnys, colAvgsPerRowSet, colCollapse,
##     colCounts, colCummaxs, colCummins, colCumprods, colCumsums,
##     colDiffs, colIQRDiffs, colIQRs, colLogSumExps, colMadDiffs,
##     colMads, colMaxs, colMeans2, colMedians, colMins, colOrderStats,
##     colProds, colQuantiles, colRanges, colRanks, colSdDiffs, colSds,
##     colSums2, colTabulates, colVarDiffs, colVars, colWeightedMads,
##     colWeightedMeans, colWeightedMedians, colWeightedSds,
##     colWeightedVars, rowAlls, rowAnyNAs, rowAnys, rowAvgsPerColSet,
##     rowCollapse, rowCounts, rowCummaxs, rowCummins, rowCumprods,
##     rowCumsums, rowDiffs, rowIQRDiffs, rowIQRs, rowLogSumExps,
##     rowMadDiffs, rowMads, rowMaxs, rowMeans2, rowMedians, rowMins,
##     rowOrderStats, rowProds, rowQuantiles, rowRanges, rowRanks,
##     rowSdDiffs, rowSds, rowSums2, rowTabulates, rowVarDiffs, rowVars,
##     rowWeightedMads, rowWeightedMeans, rowWeightedMedians,
##     rowWeightedSds, rowWeightedVars
## Loading required package: GenomicRanges
## Loading required package: stats4
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##     lapply, mapply, match, mget, order, paste, pmax, pmax.int, pmin,
##     pmin.int, rank, rbind, rownames, sapply, setdiff, table, tapply,
##     union, unique, unsplit, which.max, which.min
## Loading required package: S4Vectors
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## Attaching package: 'S4Vectors'
## The following object is masked from 'package:utils':
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## The following objects are masked from 'package:base':
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## Loading required package: IRanges
## Loading required package: GenomeInfoDb
## Loading required package: Biobase
## Welcome to Bioconductor
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##     Vignettes contain introductory material; view with
##     'browseVignettes()'. To cite Bioconductor, see
##     'citation("Biobase")', and for packages 'citation("pkgname")'.
## 
## Attaching package: 'Biobase'
## The following object is masked from 'package:MatrixGenerics':
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prism_abundances <- system.file(
    'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
    'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
    'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
    'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
                                        input_annotations = prism_annotations,
                                        input_metadata = prism_metadata,
                                        input_taxonomy = mets_taxonomy)
## 2024-06-25 18:07:14.202252 INFO::Creating output folder.
## 2024-06-25 18:07:14.215487 INFO::Writing function arguments to log file
## Samples with both abundances and metadata: 102
## 2024-06-25 18:07:14.277138 INFO::Summarized Experiment created.
## 2024-06-25 18:07:14.27863 INFO::Metadata chosen for prevalence filtering: diagnosis
## 869 features pass chosen minimum prevalence threshold of 0.7.
## Calculating pairwise correlations in phenotype: IBD
## 
## Calculating pairwise correlations in phenotype: Control
## Distance matrix with 869 features created.
## 2024-06-25 18:07:18.579305 INFO::Distance matrix with 869 metabolic features created.
## Initiating module detection
## 2024-06-25 18:07:18.580411 INFO::Minimum module size used for this dataset: 10
## Tree constructed
## Evaluating measures of success
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
##  ..cutHeight not given, setting it to 0.99  ===>  99% of the (truncated) height range in dendro.
##  ..done.
## 2024-06-25 18:07:19.937698 INFO::Total number of modules detected: 30
## Initiating AVA calculations
## Finding anchors
## Calculating AVA
## Initiating q-value calculations
## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2024-06-25 18:07:22.005096 INFO::Writing function arguments to log file
## 2024-06-25 18:07:22.010221 INFO::Verifying options selected are valid
## 2024-06-25 18:07:22.053042 INFO::Determining format of input files
## 2024-06-25 18:07:22.053999 INFO::Input format is data samples as columns and metadata samples as rows
## 2024-06-25 18:07:22.068589 INFO::Formula for fixed effects: expr ~  diagnosis + age + antibiotics
## 2024-06-25 18:07:22.070089 INFO::Filter data based on min abundance and min prevalence
## 2024-06-25 18:07:22.070712 INFO::Total samples in data: 102
## 2024-06-25 18:07:22.071291 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2024-06-25 18:07:22.082303 INFO::Total filtered features: 0
## 2024-06-25 18:07:22.083061 INFO::Filtered feature names from abundance and prevalence filtering:
## 2024-06-25 18:07:22.099305 INFO::Total filtered features with variance filtering: 0
## 2024-06-25 18:07:22.100131 INFO::Filtered feature names from variance filtering:
## 2024-06-25 18:07:22.100748 INFO::Running selected normalization method: NONE
## 2024-06-25 18:07:22.101408 INFO::Applying z-score to standardize continuous metadata
## 2024-06-25 18:07:22.124864 INFO::Running selected transform method: NONE
## 2024-06-25 18:07:22.125733 INFO::Running selected analysis method: LM
## 2024-06-25 18:07:22.130833 INFO::Fitting model to feature number 1, F1
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## 2024-06-25 18:07:22.671314 INFO::Fitting model to feature number 161, F167
## 2024-06-25 18:07:22.674467 INFO::Fitting model to feature number 162, F168
## 2024-06-25 18:07:22.677611 INFO::Fitting model to feature number 163, F169
## 2024-06-25 18:07:22.680788 INFO::Fitting model to feature number 164, F170
## 2024-06-25 18:07:22.684035 INFO::Fitting model to feature number 165, F171
## 2024-06-25 18:07:22.687337 INFO::Fitting model to feature number 166, F172
## 2024-06-25 18:07:22.690512 INFO::Fitting model to feature number 167, F173
## 2024-06-25 18:07:22.693691 INFO::Fitting model to feature number 168, F174
## 2024-06-25 18:07:22.69683 INFO::Fitting model to feature number 169, F175
## 2024-06-25 18:07:22.699963 INFO::Fitting model to feature number 170, F176
## 2024-06-25 18:07:22.703107 INFO::Fitting model to feature number 171, F177
## 2024-06-25 18:07:22.706275 INFO::Fitting model to feature number 172, F178
## 2024-06-25 18:07:22.709469 INFO::Fitting model to feature number 173, F179
## 2024-06-25 18:07:22.712656 INFO::Fitting model to feature number 174, F180
## 2024-06-25 18:07:22.715785 INFO::Fitting model to feature number 175, F181
## 2024-06-25 18:07:22.7189 INFO::Fitting model to feature number 176, F182
## 2024-06-25 18:07:22.721999 INFO::Fitting model to feature number 177, F183
## 2024-06-25 18:07:22.725096 INFO::Fitting model to feature number 178, F184
## 2024-06-25 18:07:22.728195 INFO::Fitting model to feature number 179, F185
## 2024-06-25 18:07:22.731314 INFO::Fitting model to feature number 180, F186
## 2024-06-25 18:07:22.734417 INFO::Fitting model to feature number 181, F187
## 2024-06-25 18:07:22.737505 INFO::Fitting model to feature number 182, F188
## 2024-06-25 18:07:22.74064 INFO::Fitting model to feature number 183, F189
## 2024-06-25 18:07:22.743746 INFO::Fitting model to feature number 184, F190
## 2024-06-25 18:07:22.74687 INFO::Fitting model to feature number 185, F191
## 2024-06-25 18:07:22.749996 INFO::Fitting model to feature number 186, F192
## 2024-06-25 18:07:22.753145 INFO::Fitting model to feature number 187, F193
## 2024-06-25 18:07:22.756264 INFO::Fitting model to feature number 188, F194
## 2024-06-25 18:07:22.759371 INFO::Fitting model to feature number 189, F195
## 2024-06-25 18:07:22.762499 INFO::Fitting model to feature number 190, F196
## 2024-06-25 18:07:22.765619 INFO::Fitting model to feature number 191, F197
## 2024-06-25 18:07:22.768727 INFO::Fitting model to feature number 192, F198
## 2024-06-25 18:07:22.77184 INFO::Fitting model to feature number 193, F199
## 2024-06-25 18:07:22.774962 INFO::Fitting model to feature number 194, F200
## 2024-06-25 18:07:22.778085 INFO::Fitting model to feature number 195, F201
## 2024-06-25 18:07:22.781197 INFO::Fitting model to feature number 196, F202
## 2024-06-25 18:07:22.784301 INFO::Fitting model to feature number 197, F203
## 2024-06-25 18:07:22.787424 INFO::Fitting model to feature number 198, F204
## 2024-06-25 18:07:22.790553 INFO::Fitting model to feature number 199, F206
## 2024-06-25 18:07:22.793693 INFO::Fitting model to feature number 200, F207
## 2024-06-25 18:07:22.796819 INFO::Fitting model to feature number 201, F208
## 2024-06-25 18:07:22.799937 INFO::Fitting model to feature number 202, F209
## 2024-06-25 18:07:22.803062 INFO::Fitting model to feature number 203, F210
## 2024-06-25 18:07:22.810549 INFO::Fitting model to feature number 204, F211
## 2024-06-25 18:07:22.814222 INFO::Fitting model to feature number 205, F212
## 2024-06-25 18:07:22.817821 INFO::Fitting model to feature number 206, F213
## 2024-06-25 18:07:22.821267 INFO::Fitting model to feature number 207, F214
## 2024-06-25 18:07:22.824724 INFO::Fitting model to feature number 208, F215
## 2024-06-25 18:07:22.828133 INFO::Fitting model to feature number 209, F216
## 2024-06-25 18:07:22.831541 INFO::Fitting model to feature number 210, F217
## 2024-06-25 18:07:22.834963 INFO::Fitting model to feature number 211, F218
## 2024-06-25 18:07:22.838531 INFO::Fitting model to feature number 212, F219
## 2024-06-25 18:07:22.842084 INFO::Fitting model to feature number 213, F220
## 2024-06-25 18:07:22.845787 INFO::Fitting model to feature number 214, F221
## 2024-06-25 18:07:22.849226 INFO::Fitting model to feature number 215, F222
## 2024-06-25 18:07:22.852674 INFO::Fitting model to feature number 216, F223
## 2024-06-25 18:07:22.856139 INFO::Fitting model to feature number 217, F224
## 2024-06-25 18:07:22.85961 INFO::Fitting model to feature number 218, F225
## 2024-06-25 18:07:22.863105 INFO::Fitting model to feature number 219, F226
## 2024-06-25 18:07:22.866675 INFO::Fitting model to feature number 220, F227
## 2024-06-25 18:07:22.870228 INFO::Fitting model to feature number 221, F228
## 2024-06-25 18:07:22.873725 INFO::Fitting model to feature number 222, F229
## 2024-06-25 18:07:22.877182 INFO::Fitting model to feature number 223, F230
## 2024-06-25 18:07:22.880625 INFO::Fitting model to feature number 224, F231
## 2024-06-25 18:07:22.884283 INFO::Fitting model to feature number 225, F232
## 2024-06-25 18:07:22.887712 INFO::Fitting model to feature number 226, F233
## 2024-06-25 18:07:22.891125 INFO::Fitting model to feature number 227, F234
## 2024-06-25 18:07:22.894596 INFO::Fitting model to feature number 228, F235
## 2024-06-25 18:07:22.898021 INFO::Fitting model to feature number 229, F236
## 2024-06-25 18:07:22.90148 INFO::Fitting model to feature number 230, F237
## 2024-06-25 18:07:22.904944 INFO::Fitting model to feature number 231, F238
## 2024-06-25 18:07:22.908384 INFO::Fitting model to feature number 232, F239
## 2024-06-25 18:07:22.91205 INFO::Fitting model to feature number 233, F240
## 2024-06-25 18:07:22.915684 INFO::Fitting model to feature number 234, F241
## 2024-06-25 18:07:22.919342 INFO::Fitting model to feature number 235, F242
## 2024-06-25 18:07:22.922949 INFO::Fitting model to feature number 236, F243
## 2024-06-25 18:07:22.92667 INFO::Fitting model to feature number 237, F244
## 2024-06-25 18:07:22.930258 INFO::Fitting model to feature number 238, F245
## 2024-06-25 18:07:22.933771 INFO::Fitting model to feature number 239, F246
## 2024-06-25 18:07:22.937475 INFO::Fitting model to feature number 240, F247
## 2024-06-25 18:07:22.941167 INFO::Fitting model to feature number 241, F248
## 2024-06-25 18:07:22.944782 INFO::Fitting model to feature number 242, F249
## 2024-06-25 18:07:22.948431 INFO::Fitting model to feature number 243, F250
## 2024-06-25 18:07:22.951893 INFO::Fitting model to feature number 244, F252
## 2024-06-25 18:07:22.955174 INFO::Fitting model to feature number 245, F253
## 2024-06-25 18:07:22.95847 INFO::Fitting model to feature number 246, F254
## 2024-06-25 18:07:22.961724 INFO::Fitting model to feature number 247, F255
## 2024-06-25 18:07:22.965027 INFO::Fitting model to feature number 248, F256
## 2024-06-25 18:07:22.968266 INFO::Fitting model to feature number 249, F257
## 2024-06-25 18:07:22.971479 INFO::Fitting model to feature number 250, F259
## 2024-06-25 18:07:22.974686 INFO::Fitting model to feature number 251, F260
## 2024-06-25 18:07:22.977886 INFO::Fitting model to feature number 252, F261
## 2024-06-25 18:07:22.981052 INFO::Fitting model to feature number 253, F262
## 2024-06-25 18:07:22.984228 INFO::Fitting model to feature number 254, F263
## 2024-06-25 18:07:22.987404 INFO::Fitting model to feature number 255, F264
## 2024-06-25 18:07:22.990598 INFO::Fitting model to feature number 256, F265
## 2024-06-25 18:07:22.993796 INFO::Fitting model to feature number 257, F266
## 2024-06-25 18:07:22.996982 INFO::Fitting model to feature number 258, F267
## 2024-06-25 18:07:23.000154 INFO::Fitting model to feature number 259, F269
## 2024-06-25 18:07:23.003315 INFO::Fitting model to feature number 260, F270
## 2024-06-25 18:07:23.006505 INFO::Fitting model to feature number 261, F271
## 2024-06-25 18:07:23.009706 INFO::Fitting model to feature number 262, F272
## 2024-06-25 18:07:23.012895 INFO::Fitting model to feature number 263, F273
## 2024-06-25 18:07:23.016083 INFO::Fitting model to feature number 264, F274
## 2024-06-25 18:07:23.019279 INFO::Fitting model to feature number 265, F276
## 2024-06-25 18:07:23.022442 INFO::Fitting model to feature number 266, F277
## 2024-06-25 18:07:23.025626 INFO::Fitting model to feature number 267, F278
## 2024-06-25 18:07:23.028819 INFO::Fitting model to feature number 268, F279
## 2024-06-25 18:07:23.032095 INFO::Fitting model to feature number 269, F280
## 2024-06-25 18:07:23.035277 INFO::Fitting model to feature number 270, F281
## 2024-06-25 18:07:23.03845 INFO::Fitting model to feature number 271, F282
## 2024-06-25 18:07:23.041642 INFO::Fitting model to feature number 272, F283
## 2024-06-25 18:07:23.044831 INFO::Fitting model to feature number 273, F284
## 2024-06-25 18:07:23.047991 INFO::Fitting model to feature number 274, F285
## 2024-06-25 18:07:23.051162 INFO::Fitting model to feature number 275, F286
## 2024-06-25 18:07:23.054359 INFO::Fitting model to feature number 276, F287
## 2024-06-25 18:07:23.05756 INFO::Fitting model to feature number 277, F288
## 2024-06-25 18:07:23.060743 INFO::Fitting model to feature number 278, F289
## 2024-06-25 18:07:23.063913 INFO::Fitting model to feature number 279, F290
## 2024-06-25 18:07:23.067087 INFO::Fitting model to feature number 280, F292
## 2024-06-25 18:07:23.070272 INFO::Fitting model to feature number 281, F293
## 2024-06-25 18:07:23.073465 INFO::Fitting model to feature number 282, F294
## 2024-06-25 18:07:23.076663 INFO::Fitting model to feature number 283, F295
## 2024-06-25 18:07:23.079845 INFO::Fitting model to feature number 284, F296
## 2024-06-25 18:07:23.083035 INFO::Fitting model to feature number 285, F297
## 2024-06-25 18:07:23.086219 INFO::Fitting model to feature number 286, F298
## 2024-06-25 18:07:23.089428 INFO::Fitting model to feature number 287, F299
## 2024-06-25 18:07:23.092625 INFO::Fitting model to feature number 288, F300
## 2024-06-25 18:07:23.095802 INFO::Fitting model to feature number 289, F301
## 2024-06-25 18:07:23.099006 INFO::Fitting model to feature number 290, F302
## 2024-06-25 18:07:23.102199 INFO::Fitting model to feature number 291, F303
## 2024-06-25 18:07:23.105391 INFO::Fitting model to feature number 292, F304
## 2024-06-25 18:07:23.108592 INFO::Fitting model to feature number 293, F305
## 2024-06-25 18:07:23.111707 INFO::Fitting model to feature number 294, F306
## 2024-06-25 18:07:23.114883 INFO::Fitting model to feature number 295, F307
## 2024-06-25 18:07:23.118063 INFO::Fitting model to feature number 296, F308
## 2024-06-25 18:07:23.121297 INFO::Fitting model to feature number 297, F309
## 2024-06-25 18:07:23.124537 INFO::Fitting model to feature number 298, F310
## 2024-06-25 18:07:23.14624 INFO::Fitting model to feature number 299, F311
## 2024-06-25 18:07:23.149584 INFO::Fitting model to feature number 300, F312
## 2024-06-25 18:07:23.152856 INFO::Fitting model to feature number 301, F313
## 2024-06-25 18:07:23.156044 INFO::Fitting model to feature number 302, F315
## 2024-06-25 18:07:23.159214 INFO::Fitting model to feature number 303, F316
## 2024-06-25 18:07:23.16239 INFO::Fitting model to feature number 304, F317
## 2024-06-25 18:07:23.165565 INFO::Fitting model to feature number 305, F318
## 2024-06-25 18:07:23.168722 INFO::Fitting model to feature number 306, F319
## 2024-06-25 18:07:23.171887 INFO::Fitting model to feature number 307, F320
## 2024-06-25 18:07:23.17505 INFO::Fitting model to feature number 308, F321
## 2024-06-25 18:07:23.178232 INFO::Fitting model to feature number 309, F322
## 2024-06-25 18:07:23.181411 INFO::Fitting model to feature number 310, F323
## 2024-06-25 18:07:23.184609 INFO::Fitting model to feature number 311, F324
## 2024-06-25 18:07:23.187779 INFO::Fitting model to feature number 312, F325
## 2024-06-25 18:07:23.190979 INFO::Fitting model to feature number 313, F326
## 2024-06-25 18:07:23.194175 INFO::Fitting model to feature number 314, F327
## 2024-06-25 18:07:23.197374 INFO::Fitting model to feature number 315, F328
## 2024-06-25 18:07:23.20055 INFO::Fitting model to feature number 316, F329
## 2024-06-25 18:07:23.20371 INFO::Fitting model to feature number 317, F330
## 2024-06-25 18:07:23.20683 INFO::Fitting model to feature number 318, F331
## 2024-06-25 18:07:23.210031 INFO::Fitting model to feature number 319, F332
## 2024-06-25 18:07:23.213201 INFO::Fitting model to feature number 320, F333
## 2024-06-25 18:07:23.216343 INFO::Fitting model to feature number 321, F334
## 2024-06-25 18:07:23.219526 INFO::Fitting model to feature number 322, F335
## 2024-06-25 18:07:23.222748 INFO::Fitting model to feature number 323, F336
## 2024-06-25 18:07:23.225971 INFO::Fitting model to feature number 324, F337
## 2024-06-25 18:07:23.229156 INFO::Fitting model to feature number 325, F338
## 2024-06-25 18:07:23.232343 INFO::Fitting model to feature number 326, F339
## 2024-06-25 18:07:23.235526 INFO::Fitting model to feature number 327, F340
## 2024-06-25 18:07:23.238795 INFO::Fitting model to feature number 328, F342
## 2024-06-25 18:07:23.241982 INFO::Fitting model to feature number 329, F343
## 2024-06-25 18:07:23.245185 INFO::Fitting model to feature number 330, F344
## 2024-06-25 18:07:23.248405 INFO::Fitting model to feature number 331, F345
## 2024-06-25 18:07:23.251599 INFO::Fitting model to feature number 332, F346
## 2024-06-25 18:07:23.254938 INFO::Fitting model to feature number 333, F347
## 2024-06-25 18:07:23.258084 INFO::Fitting model to feature number 334, F348
## 2024-06-25 18:07:23.261232 INFO::Fitting model to feature number 335, F350
## 2024-06-25 18:07:23.264369 INFO::Fitting model to feature number 336, F351
## 2024-06-25 18:07:23.267505 INFO::Fitting model to feature number 337, F352
## 2024-06-25 18:07:23.270634 INFO::Fitting model to feature number 338, F353
## 2024-06-25 18:07:23.273764 INFO::Fitting model to feature number 339, F355
## 2024-06-25 18:07:23.276895 INFO::Fitting model to feature number 340, F356
## 2024-06-25 18:07:23.280056 INFO::Fitting model to feature number 341, F357
## 2024-06-25 18:07:23.283224 INFO::Fitting model to feature number 342, F358
## 2024-06-25 18:07:23.286362 INFO::Fitting model to feature number 343, F359
## 2024-06-25 18:07:23.289439 INFO::Fitting model to feature number 344, F360
## 2024-06-25 18:07:23.292562 INFO::Fitting model to feature number 345, F361
## 2024-06-25 18:07:23.295691 INFO::Fitting model to feature number 346, F362
## 2024-06-25 18:07:23.298821 INFO::Fitting model to feature number 347, F363
## 2024-06-25 18:07:23.301981 INFO::Fitting model to feature number 348, F364
## 2024-06-25 18:07:23.305152 INFO::Fitting model to feature number 349, F365
## 2024-06-25 18:07:23.308374 INFO::Fitting model to feature number 350, F366
## 2024-06-25 18:07:23.31164 INFO::Fitting model to feature number 351, F367
## 2024-06-25 18:07:23.314972 INFO::Fitting model to feature number 352, F368
## 2024-06-25 18:07:23.318304 INFO::Fitting model to feature number 353, F369
## 2024-06-25 18:07:23.321669 INFO::Fitting model to feature number 354, F370
## 2024-06-25 18:07:23.325074 INFO::Fitting model to feature number 355, F371
## 2024-06-25 18:07:23.328414 INFO::Fitting model to feature number 356, F372
## 2024-06-25 18:07:23.33173 INFO::Fitting model to feature number 357, F373
## 2024-06-25 18:07:23.334974 INFO::Fitting model to feature number 358, F374
## 2024-06-25 18:07:23.338202 INFO::Fitting model to feature number 359, F375
## 2024-06-25 18:07:23.341377 INFO::Fitting model to feature number 360, F376
## 2024-06-25 18:07:23.344538 INFO::Fitting model to feature number 361, F377
## 2024-06-25 18:07:23.347663 INFO::Fitting model to feature number 362, F378
## 2024-06-25 18:07:23.350803 INFO::Fitting model to feature number 363, F379
## 2024-06-25 18:07:23.354168 INFO::Fitting model to feature number 364, F380
## 2024-06-25 18:07:23.357444 INFO::Fitting model to feature number 365, F381
## 2024-06-25 18:07:23.360588 INFO::Fitting model to feature number 366, F382
## 2024-06-25 18:07:23.363722 INFO::Fitting model to feature number 367, F383
## 2024-06-25 18:07:23.366885 INFO::Fitting model to feature number 368, F384
## 2024-06-25 18:07:23.370079 INFO::Fitting model to feature number 369, F386
## 2024-06-25 18:07:23.373312 INFO::Fitting model to feature number 370, F387
## 2024-06-25 18:07:23.376451 INFO::Fitting model to feature number 371, F388
## 2024-06-25 18:07:23.379591 INFO::Fitting model to feature number 372, F389
## 2024-06-25 18:07:23.38271 INFO::Fitting model to feature number 373, F390
## 2024-06-25 18:07:23.385869 INFO::Fitting model to feature number 374, F391
## 2024-06-25 18:07:23.389041 INFO::Fitting model to feature number 375, F392
## 2024-06-25 18:07:23.392172 INFO::Fitting model to feature number 376, F393
## 2024-06-25 18:07:23.39535 INFO::Fitting model to feature number 377, F394
## 2024-06-25 18:07:23.39851 INFO::Fitting model to feature number 378, F395
## 2024-06-25 18:07:23.401608 INFO::Fitting model to feature number 379, F396
## 2024-06-25 18:07:23.404758 INFO::Fitting model to feature number 380, F397
## 2024-06-25 18:07:23.407897 INFO::Fitting model to feature number 381, F398
## 2024-06-25 18:07:23.411048 INFO::Fitting model to feature number 382, F399
## 2024-06-25 18:07:23.414211 INFO::Fitting model to feature number 383, F400
## 2024-06-25 18:07:23.41735 INFO::Fitting model to feature number 384, F401
## 2024-06-25 18:07:23.420407 INFO::Fitting model to feature number 385, F402
## 2024-06-25 18:07:23.423532 INFO::Fitting model to feature number 386, F403
## 2024-06-25 18:07:23.42668 INFO::Fitting model to feature number 387, F404
## 2024-06-25 18:07:23.429828 INFO::Fitting model to feature number 388, F406
## 2024-06-25 18:07:23.432963 INFO::Fitting model to feature number 389, F407
## 2024-06-25 18:07:23.436089 INFO::Fitting model to feature number 390, F408
## 2024-06-25 18:07:23.439255 INFO::Fitting model to feature number 391, F409
## 2024-06-25 18:07:23.442401 INFO::Fitting model to feature number 392, F410
## 2024-06-25 18:07:23.445533 INFO::Fitting model to feature number 393, F411
## 2024-06-25 18:07:23.448683 INFO::Fitting model to feature number 394, F412
## 2024-06-25 18:07:23.451756 INFO::Fitting model to feature number 395, F413
## 2024-06-25 18:07:23.454898 INFO::Fitting model to feature number 396, F414
## 2024-06-25 18:07:23.458056 INFO::Fitting model to feature number 397, F415
## 2024-06-25 18:07:23.461233 INFO::Fitting model to feature number 398, F416
## 2024-06-25 18:07:23.464412 INFO::Fitting model to feature number 399, F417
## 2024-06-25 18:07:23.467615 INFO::Fitting model to feature number 400, F418
## 2024-06-25 18:07:23.470868 INFO::Fitting model to feature number 401, F419
## 2024-06-25 18:07:23.474238 INFO::Fitting model to feature number 402, F420
## 2024-06-25 18:07:23.477564 INFO::Fitting model to feature number 403, F421
## 2024-06-25 18:07:23.480926 INFO::Fitting model to feature number 404, F422
## 2024-06-25 18:07:23.484229 INFO::Fitting model to feature number 405, F423
## 2024-06-25 18:07:23.487622 INFO::Fitting model to feature number 406, F425
## 2024-06-25 18:07:23.491031 INFO::Fitting model to feature number 407, F426
## 2024-06-25 18:07:23.494303 INFO::Fitting model to feature number 408, F428
## 2024-06-25 18:07:23.497416 INFO::Fitting model to feature number 409, F429
## 2024-06-25 18:07:23.500569 INFO::Fitting model to feature number 410, F430
## 2024-06-25 18:07:23.503681 INFO::Fitting model to feature number 411, F431
## 2024-06-25 18:07:23.506852 INFO::Fitting model to feature number 412, F432
## 2024-06-25 18:07:23.509992 INFO::Fitting model to feature number 413, F433
## 2024-06-25 18:07:23.513094 INFO::Fitting model to feature number 414, F434
## 2024-06-25 18:07:23.516196 INFO::Fitting model to feature number 415, F435
## 2024-06-25 18:07:23.519374 INFO::Fitting model to feature number 416, F436
## 2024-06-25 18:07:23.522519 INFO::Fitting model to feature number 417, F437
## 2024-06-25 18:07:23.525725 INFO::Fitting model to feature number 418, F438
## 2024-06-25 18:07:23.528897 INFO::Fitting model to feature number 419, F439
## 2024-06-25 18:07:23.53206 INFO::Fitting model to feature number 420, F440
## 2024-06-25 18:07:23.535261 INFO::Fitting model to feature number 421, F441
## 2024-06-25 18:07:23.538471 INFO::Fitting model to feature number 422, F442
## 2024-06-25 18:07:23.541671 INFO::Fitting model to feature number 423, F443
## 2024-06-25 18:07:23.544881 INFO::Fitting model to feature number 424, F444
## 2024-06-25 18:07:23.548021 INFO::Fitting model to feature number 425, F445
## 2024-06-25 18:07:23.55114 INFO::Fitting model to feature number 426, F446
## 2024-06-25 18:07:23.554261 INFO::Fitting model to feature number 427, F447
## 2024-06-25 18:07:23.557391 INFO::Fitting model to feature number 428, F448
## 2024-06-25 18:07:23.560531 INFO::Fitting model to feature number 429, F449
## 2024-06-25 18:07:23.563678 INFO::Fitting model to feature number 430, F450
## 2024-06-25 18:07:23.566804 INFO::Fitting model to feature number 431, F451
## 2024-06-25 18:07:23.569971 INFO::Fitting model to feature number 432, F452
## 2024-06-25 18:07:23.573132 INFO::Fitting model to feature number 433, F454
## 2024-06-25 18:07:23.576286 INFO::Fitting model to feature number 434, F455
## 2024-06-25 18:07:23.579437 INFO::Fitting model to feature number 435, F456
## 2024-06-25 18:07:23.582599 INFO::Fitting model to feature number 436, F457
## 2024-06-25 18:07:23.585772 INFO::Fitting model to feature number 437, F458
## 2024-06-25 18:07:23.588989 INFO::Fitting model to feature number 438, F459
## 2024-06-25 18:07:23.592166 INFO::Fitting model to feature number 439, F461
## 2024-06-25 18:07:23.595362 INFO::Fitting model to feature number 440, F462
## 2024-06-25 18:07:23.598552 INFO::Fitting model to feature number 441, F463
## 2024-06-25 18:07:23.601744 INFO::Fitting model to feature number 442, F464
## 2024-06-25 18:07:23.604929 INFO::Fitting model to feature number 443, F465
## 2024-06-25 18:07:23.608121 INFO::Fitting model to feature number 444, F466
## 2024-06-25 18:07:23.611338 INFO::Fitting model to feature number 445, F467
## 2024-06-25 18:07:23.614583 INFO::Fitting model to feature number 446, F468
## 2024-06-25 18:07:23.617825 INFO::Fitting model to feature number 447, F469
## 2024-06-25 18:07:23.621101 INFO::Fitting model to feature number 448, F470
## 2024-06-25 18:07:23.624335 INFO::Fitting model to feature number 449, F471
## 2024-06-25 18:07:23.627583 INFO::Fitting model to feature number 450, F474
## 2024-06-25 18:07:23.630823 INFO::Fitting model to feature number 451, F475
## 2024-06-25 18:07:23.634054 INFO::Fitting model to feature number 452, F476
## 2024-06-25 18:07:23.637285 INFO::Fitting model to feature number 453, F477
## 2024-06-25 18:07:23.640547 INFO::Fitting model to feature number 454, F478
## 2024-06-25 18:07:23.643809 INFO::Fitting model to feature number 455, F479
## 2024-06-25 18:07:23.647057 INFO::Fitting model to feature number 456, F480
## 2024-06-25 18:07:23.650275 INFO::Fitting model to feature number 457, F481
## 2024-06-25 18:07:23.653505 INFO::Fitting model to feature number 458, F482
## 2024-06-25 18:07:23.656751 INFO::Fitting model to feature number 459, F483
## 2024-06-25 18:07:23.65999 INFO::Fitting model to feature number 460, F484
## 2024-06-25 18:07:23.663244 INFO::Fitting model to feature number 461, F485
## 2024-06-25 18:07:23.666506 INFO::Fitting model to feature number 462, F486
## 2024-06-25 18:07:23.669749 INFO::Fitting model to feature number 463, F487
## 2024-06-25 18:07:23.673012 INFO::Fitting model to feature number 464, F488
## 2024-06-25 18:07:23.676266 INFO::Fitting model to feature number 465, F489
## 2024-06-25 18:07:23.679534 INFO::Fitting model to feature number 466, F490
## 2024-06-25 18:07:23.682787 INFO::Fitting model to feature number 467, F491
## 2024-06-25 18:07:23.68604 INFO::Fitting model to feature number 468, F492
## 2024-06-25 18:07:23.689293 INFO::Fitting model to feature number 469, F493
## 2024-06-25 18:07:23.692562 INFO::Fitting model to feature number 470, F494
## 2024-06-25 18:07:23.695735 INFO::Fitting model to feature number 471, F495
## 2024-06-25 18:07:23.698966 INFO::Fitting model to feature number 472, F496
## 2024-06-25 18:07:23.702193 INFO::Fitting model to feature number 473, F497
## 2024-06-25 18:07:23.705403 INFO::Fitting model to feature number 474, F498
## 2024-06-25 18:07:23.708613 INFO::Fitting model to feature number 475, F499
## 2024-06-25 18:07:23.711815 INFO::Fitting model to feature number 476, F500
## 2024-06-25 18:07:23.715034 INFO::Fitting model to feature number 477, F501
## 2024-06-25 18:07:23.718241 INFO::Fitting model to feature number 478, F502
## 2024-06-25 18:07:23.721464 INFO::Fitting model to feature number 479, F503
## 2024-06-25 18:07:23.724676 INFO::Fitting model to feature number 480, F504
## 2024-06-25 18:07:23.727875 INFO::Fitting model to feature number 481, F505
## 2024-06-25 18:07:23.73107 INFO::Fitting model to feature number 482, F506
## 2024-06-25 18:07:23.734286 INFO::Fitting model to feature number 483, F507
## 2024-06-25 18:07:23.737485 INFO::Fitting model to feature number 484, F508
## 2024-06-25 18:07:23.740683 INFO::Fitting model to feature number 485, F509
## 2024-06-25 18:07:23.743869 INFO::Fitting model to feature number 486, F510
## 2024-06-25 18:07:23.747082 INFO::Fitting model to feature number 487, F511
## 2024-06-25 18:07:23.750278 INFO::Fitting model to feature number 488, F512
## 2024-06-25 18:07:23.753489 INFO::Fitting model to feature number 489, F513
## 2024-06-25 18:07:23.756699 INFO::Fitting model to feature number 490, F514
## 2024-06-25 18:07:23.759896 INFO::Fitting model to feature number 491, F515
## 2024-06-25 18:07:23.763105 INFO::Fitting model to feature number 492, F516
## 2024-06-25 18:07:23.766299 INFO::Fitting model to feature number 493, F517
## 2024-06-25 18:07:23.769515 INFO::Fitting model to feature number 494, F518
## 2024-06-25 18:07:23.772714 INFO::Fitting model to feature number 495, F519
## 2024-06-25 18:07:23.776023 INFO::Fitting model to feature number 496, F520
## 2024-06-25 18:07:23.793406 INFO::Fitting model to feature number 497, F521
## 2024-06-25 18:07:23.796885 INFO::Fitting model to feature number 498, F522
## 2024-06-25 18:07:23.80021 INFO::Fitting model to feature number 499, F523
## 2024-06-25 18:07:23.803495 INFO::Fitting model to feature number 500, F524
## 2024-06-25 18:07:23.806715 INFO::Fitting model to feature number 501, F525
## 2024-06-25 18:07:23.809929 INFO::Fitting model to feature number 502, F526
## 2024-06-25 18:07:23.813134 INFO::Fitting model to feature number 503, F527
## 2024-06-25 18:07:23.816304 INFO::Fitting model to feature number 504, F528
## 2024-06-25 18:07:23.81949 INFO::Fitting model to feature number 505, F529
## 2024-06-25 18:07:23.822661 INFO::Fitting model to feature number 506, F530
## 2024-06-25 18:07:23.825838 INFO::Fitting model to feature number 507, F531
## 2024-06-25 18:07:23.829 INFO::Fitting model to feature number 508, F532
## 2024-06-25 18:07:23.832159 INFO::Fitting model to feature number 509, F533
## 2024-06-25 18:07:23.835346 INFO::Fitting model to feature number 510, F534
## 2024-06-25 18:07:23.838517 INFO::Fitting model to feature number 511, F535
## 2024-06-25 18:07:23.841686 INFO::Fitting model to feature number 512, F536
## 2024-06-25 18:07:23.84485 INFO::Fitting model to feature number 513, F537
## 2024-06-25 18:07:23.847996 INFO::Fitting model to feature number 514, F539
## 2024-06-25 18:07:23.851165 INFO::Fitting model to feature number 515, F540
## 2024-06-25 18:07:23.854315 INFO::Fitting model to feature number 516, F541
## 2024-06-25 18:07:23.857476 INFO::Fitting model to feature number 517, F543
## 2024-06-25 18:07:23.860644 INFO::Fitting model to feature number 518, F544
## 2024-06-25 18:07:23.863767 INFO::Fitting model to feature number 519, F545
## 2024-06-25 18:07:23.866951 INFO::Fitting model to feature number 520, F546
## 2024-06-25 18:07:23.870135 INFO::Fitting model to feature number 521, F547
## 2024-06-25 18:07:23.873301 INFO::Fitting model to feature number 522, F548
## 2024-06-25 18:07:23.876454 INFO::Fitting model to feature number 523, F549
## 2024-06-25 18:07:23.879604 INFO::Fitting model to feature number 524, F550
## 2024-06-25 18:07:23.882778 INFO::Fitting model to feature number 525, F551
## 2024-06-25 18:07:23.885947 INFO::Fitting model to feature number 526, F552
## 2024-06-25 18:07:23.889115 INFO::Fitting model to feature number 527, F553
## 2024-06-25 18:07:23.892258 INFO::Fitting model to feature number 528, F554
## 2024-06-25 18:07:23.89541 INFO::Fitting model to feature number 529, F555
## 2024-06-25 18:07:23.898609 INFO::Fitting model to feature number 530, F556
## 2024-06-25 18:07:23.901813 INFO::Fitting model to feature number 531, F557
## 2024-06-25 18:07:23.905022 INFO::Fitting model to feature number 532, F558
## 2024-06-25 18:07:23.908227 INFO::Fitting model to feature number 533, F559
## 2024-06-25 18:07:23.911421 INFO::Fitting model to feature number 534, F560
## 2024-06-25 18:07:23.914597 INFO::Fitting model to feature number 535, F561
## 2024-06-25 18:07:23.917771 INFO::Fitting model to feature number 536, F562
## 2024-06-25 18:07:23.920939 INFO::Fitting model to feature number 537, F563
## 2024-06-25 18:07:23.924022 INFO::Fitting model to feature number 538, F564
## 2024-06-25 18:07:23.927209 INFO::Fitting model to feature number 539, F566
## 2024-06-25 18:07:23.930397 INFO::Fitting model to feature number 540, F567
## 2024-06-25 18:07:23.933561 INFO::Fitting model to feature number 541, F568
## 2024-06-25 18:07:23.936731 INFO::Fitting model to feature number 542, F569
## 2024-06-25 18:07:23.939891 INFO::Fitting model to feature number 543, F570
## 2024-06-25 18:07:23.943094 INFO::Fitting model to feature number 544, F571
## 2024-06-25 18:07:23.946229 INFO::Fitting model to feature number 545, F572
## 2024-06-25 18:07:23.94935 INFO::Fitting model to feature number 546, F573
## 2024-06-25 18:07:23.952471 INFO::Fitting model to feature number 547, F574
## 2024-06-25 18:07:23.955584 INFO::Fitting model to feature number 548, F575
## 2024-06-25 18:07:23.95872 INFO::Fitting model to feature number 549, F576
## 2024-06-25 18:07:23.961841 INFO::Fitting model to feature number 550, F577
## 2024-06-25 18:07:23.964969 INFO::Fitting model to feature number 551, F578
## 2024-06-25 18:07:23.968077 INFO::Fitting model to feature number 552, F579
## 2024-06-25 18:07:23.971206 INFO::Fitting model to feature number 553, F580
## 2024-06-25 18:07:23.974329 INFO::Fitting model to feature number 554, F581
## 2024-06-25 18:07:23.977455 INFO::Fitting model to feature number 555, F582
## 2024-06-25 18:07:23.980562 INFO::Fitting model to feature number 556, F583
## 2024-06-25 18:07:23.983669 INFO::Fitting model to feature number 557, F584
## 2024-06-25 18:07:23.98679 INFO::Fitting model to feature number 558, F585
## 2024-06-25 18:07:23.989924 INFO::Fitting model to feature number 559, F586
## 2024-06-25 18:07:23.993031 INFO::Fitting model to feature number 560, F587
## 2024-06-25 18:07:23.996145 INFO::Fitting model to feature number 561, F588
## 2024-06-25 18:07:23.999248 INFO::Fitting model to feature number 562, F589
## 2024-06-25 18:07:24.002366 INFO::Fitting model to feature number 563, F590
## 2024-06-25 18:07:24.005496 INFO::Fitting model to feature number 564, F591
## 2024-06-25 18:07:24.008629 INFO::Fitting model to feature number 565, F592
## 2024-06-25 18:07:24.011755 INFO::Fitting model to feature number 566, F593
## 2024-06-25 18:07:24.014888 INFO::Fitting model to feature number 567, F594
## 2024-06-25 18:07:24.018043 INFO::Fitting model to feature number 568, F595
## 2024-06-25 18:07:24.02119 INFO::Fitting model to feature number 569, F596
## 2024-06-25 18:07:24.024296 INFO::Fitting model to feature number 570, F597
## 2024-06-25 18:07:24.027409 INFO::Fitting model to feature number 571, F598
## 2024-06-25 18:07:24.030516 INFO::Fitting model to feature number 572, F599
## 2024-06-25 18:07:24.03361 INFO::Fitting model to feature number 573, F600
## 2024-06-25 18:07:24.03673 INFO::Fitting model to feature number 574, F601
## 2024-06-25 18:07:24.03986 INFO::Fitting model to feature number 575, F602
## 2024-06-25 18:07:24.042996 INFO::Fitting model to feature number 576, F603
## 2024-06-25 18:07:24.04612 INFO::Fitting model to feature number 577, F605
## 2024-06-25 18:07:24.049249 INFO::Fitting model to feature number 578, F606
## 2024-06-25 18:07:24.052358 INFO::Fitting model to feature number 579, F607
## 2024-06-25 18:07:24.055463 INFO::Fitting model to feature number 580, F608
## 2024-06-25 18:07:24.058566 INFO::Fitting model to feature number 581, F609
## 2024-06-25 18:07:24.061669 INFO::Fitting model to feature number 582, F610
## 2024-06-25 18:07:24.064792 INFO::Fitting model to feature number 583, F611
## 2024-06-25 18:07:24.067892 INFO::Fitting model to feature number 584, F612
## 2024-06-25 18:07:24.071005 INFO::Fitting model to feature number 585, F613
## 2024-06-25 18:07:24.074119 INFO::Fitting model to feature number 586, F614
## 2024-06-25 18:07:24.077244 INFO::Fitting model to feature number 587, F615
## 2024-06-25 18:07:24.080358 INFO::Fitting model to feature number 588, F616
## 2024-06-25 18:07:24.083472 INFO::Fitting model to feature number 589, F617
## 2024-06-25 18:07:24.086607 INFO::Fitting model to feature number 590, F618
## 2024-06-25 18:07:24.089726 INFO::Fitting model to feature number 591, F619
## 2024-06-25 18:07:24.092851 INFO::Fitting model to feature number 592, F620
## 2024-06-25 18:07:24.095897 INFO::Fitting model to feature number 593, F621
## 2024-06-25 18:07:24.099027 INFO::Fitting model to feature number 594, F622
## 2024-06-25 18:07:24.102155 INFO::Fitting model to feature number 595, F623
## 2024-06-25 18:07:24.105264 INFO::Fitting model to feature number 596, F624
## 2024-06-25 18:07:24.108371 INFO::Fitting model to feature number 597, F625
## 2024-06-25 18:07:24.111497 INFO::Fitting model to feature number 598, F626
## 2024-06-25 18:07:24.114618 INFO::Fitting model to feature number 599, F627
## 2024-06-25 18:07:24.117731 INFO::Fitting model to feature number 600, F628
## 2024-06-25 18:07:24.120858 INFO::Fitting model to feature number 601, F629
## 2024-06-25 18:07:24.123962 INFO::Fitting model to feature number 602, F630
## 2024-06-25 18:07:24.127069 INFO::Fitting model to feature number 603, F631
## 2024-06-25 18:07:24.130189 INFO::Fitting model to feature number 604, F632
## 2024-06-25 18:07:24.133301 INFO::Fitting model to feature number 605, F633
## 2024-06-25 18:07:24.136403 INFO::Fitting model to feature number 606, F634
## 2024-06-25 18:07:24.139491 INFO::Fitting model to feature number 607, F635
## 2024-06-25 18:07:24.142603 INFO::Fitting model to feature number 608, F636
## 2024-06-25 18:07:24.145759 INFO::Fitting model to feature number 609, F637
## 2024-06-25 18:07:24.148884 INFO::Fitting model to feature number 610, F638
## 2024-06-25 18:07:24.151993 INFO::Fitting model to feature number 611, F639
## 2024-06-25 18:07:24.155146 INFO::Fitting model to feature number 612, F640
## 2024-06-25 18:07:24.158309 INFO::Fitting model to feature number 613, F641
## 2024-06-25 18:07:24.161467 INFO::Fitting model to feature number 614, F642
## 2024-06-25 18:07:24.164619 INFO::Fitting model to feature number 615, F643
## 2024-06-25 18:07:24.167796 INFO::Fitting model to feature number 616, F644
## 2024-06-25 18:07:24.170976 INFO::Fitting model to feature number 617, F645
## 2024-06-25 18:07:24.174115 INFO::Fitting model to feature number 618, F646
## 2024-06-25 18:07:24.177254 INFO::Fitting model to feature number 619, F647
## 2024-06-25 18:07:24.180383 INFO::Fitting model to feature number 620, F648
## 2024-06-25 18:07:24.183521 INFO::Fitting model to feature number 621, F649
## 2024-06-25 18:07:24.18669 INFO::Fitting model to feature number 622, F650
## 2024-06-25 18:07:24.189861 INFO::Fitting model to feature number 623, F651
## 2024-06-25 18:07:24.192997 INFO::Fitting model to feature number 624, F652
## 2024-06-25 18:07:24.196111 INFO::Fitting model to feature number 625, F653
## 2024-06-25 18:07:24.199248 INFO::Fitting model to feature number 626, F654
## 2024-06-25 18:07:24.202314 INFO::Fitting model to feature number 627, F655
## 2024-06-25 18:07:24.205481 INFO::Fitting model to feature number 628, F656
## 2024-06-25 18:07:24.208657 INFO::Fitting model to feature number 629, F657
## 2024-06-25 18:07:24.211798 INFO::Fitting model to feature number 630, F658
## 2024-06-25 18:07:24.214937 INFO::Fitting model to feature number 631, F659
## 2024-06-25 18:07:24.218114 INFO::Fitting model to feature number 632, F660
## 2024-06-25 18:07:24.221298 INFO::Fitting model to feature number 633, F661
## 2024-06-25 18:07:24.224468 INFO::Fitting model to feature number 634, F662
## 2024-06-25 18:07:24.227622 INFO::Fitting model to feature number 635, F663
## 2024-06-25 18:07:24.230851 INFO::Fitting model to feature number 636, F664
## 2024-06-25 18:07:24.23406 INFO::Fitting model to feature number 637, F665
## 2024-06-25 18:07:24.237284 INFO::Fitting model to feature number 638, F666
## 2024-06-25 18:07:24.240508 INFO::Fitting model to feature number 639, F667
## 2024-06-25 18:07:24.243694 INFO::Fitting model to feature number 640, F668
## 2024-06-25 18:07:24.246882 INFO::Fitting model to feature number 641, F669
## 2024-06-25 18:07:24.250074 INFO::Fitting model to feature number 642, F670
## 2024-06-25 18:07:24.253248 INFO::Fitting model to feature number 643, F671
## 2024-06-25 18:07:24.256436 INFO::Fitting model to feature number 644, F672
## 2024-06-25 18:07:24.259594 INFO::Fitting model to feature number 645, F673
## 2024-06-25 18:07:24.262763 INFO::Fitting model to feature number 646, F674
## 2024-06-25 18:07:24.26602 INFO::Fitting model to feature number 647, F675
## 2024-06-25 18:07:24.269267 INFO::Fitting model to feature number 648, F676
## 2024-06-25 18:07:24.272516 INFO::Fitting model to feature number 649, F677
## 2024-06-25 18:07:24.27575 INFO::Fitting model to feature number 650, F678
## 2024-06-25 18:07:24.278982 INFO::Fitting model to feature number 651, F679
## 2024-06-25 18:07:24.282228 INFO::Fitting model to feature number 652, F680
## 2024-06-25 18:07:24.285472 INFO::Fitting model to feature number 653, F681
## 2024-06-25 18:07:24.288696 INFO::Fitting model to feature number 654, F682
## 2024-06-25 18:07:24.291899 INFO::Fitting model to feature number 655, F683
## 2024-06-25 18:07:24.295052 INFO::Fitting model to feature number 656, F684
## 2024-06-25 18:07:24.298255 INFO::Fitting model to feature number 657, F685
## 2024-06-25 18:07:24.301537 INFO::Fitting model to feature number 658, F686
## 2024-06-25 18:07:24.304789 INFO::Fitting model to feature number 659, F687
## 2024-06-25 18:07:24.308 INFO::Fitting model to feature number 660, F688
## 2024-06-25 18:07:24.31118 INFO::Fitting model to feature number 661, F689
## 2024-06-25 18:07:24.314363 INFO::Fitting model to feature number 662, F690
## 2024-06-25 18:07:24.317544 INFO::Fitting model to feature number 663, F691
## 2024-06-25 18:07:24.320746 INFO::Fitting model to feature number 664, F692
## 2024-06-25 18:07:24.323926 INFO::Fitting model to feature number 665, F693
## 2024-06-25 18:07:24.327119 INFO::Fitting model to feature number 666, F694
## 2024-06-25 18:07:24.330306 INFO::Fitting model to feature number 667, F695
## 2024-06-25 18:07:24.333477 INFO::Fitting model to feature number 668, F696
## 2024-06-25 18:07:24.33668 INFO::Fitting model to feature number 669, F697
## 2024-06-25 18:07:24.339792 INFO::Fitting model to feature number 670, F698
## 2024-06-25 18:07:24.343005 INFO::Fitting model to feature number 671, F699
## 2024-06-25 18:07:24.346203 INFO::Fitting model to feature number 672, F700
## 2024-06-25 18:07:24.349387 INFO::Fitting model to feature number 673, F701
## 2024-06-25 18:07:24.352562 INFO::Fitting model to feature number 674, F702
## 2024-06-25 18:07:24.355731 INFO::Fitting model to feature number 675, F704
## 2024-06-25 18:07:24.358935 INFO::Fitting model to feature number 676, F705
## 2024-06-25 18:07:24.362138 INFO::Fitting model to feature number 677, F706
## 2024-06-25 18:07:24.365321 INFO::Fitting model to feature number 678, F707
## 2024-06-25 18:07:24.368502 INFO::Fitting model to feature number 679, F708
## 2024-06-25 18:07:24.371673 INFO::Fitting model to feature number 680, F709
## 2024-06-25 18:07:24.374875 INFO::Fitting model to feature number 681, F710
## 2024-06-25 18:07:24.378072 INFO::Fitting model to feature number 682, F711
## 2024-06-25 18:07:24.381261 INFO::Fitting model to feature number 683, F712
## 2024-06-25 18:07:24.384441 INFO::Fitting model to feature number 684, F713
## 2024-06-25 18:07:24.387633 INFO::Fitting model to feature number 685, F714
## 2024-06-25 18:07:24.390831 INFO::Fitting model to feature number 686, F715
## 2024-06-25 18:07:24.394016 INFO::Fitting model to feature number 687, F716
## 2024-06-25 18:07:24.3972 INFO::Fitting model to feature number 688, F717
## 2024-06-25 18:07:24.412932 INFO::Fitting model to feature number 689, F718
## 2024-06-25 18:07:24.417233 INFO::Fitting model to feature number 690, F719
## 2024-06-25 18:07:24.420536 INFO::Fitting model to feature number 691, F720
## 2024-06-25 18:07:24.423782 INFO::Fitting model to feature number 692, F721
## 2024-06-25 18:07:24.426963 INFO::Fitting model to feature number 693, F722
## 2024-06-25 18:07:24.430146 INFO::Fitting model to feature number 694, F723
## 2024-06-25 18:07:24.433327 INFO::Fitting model to feature number 695, F724
## 2024-06-25 18:07:24.436497 INFO::Fitting model to feature number 696, F725
## 2024-06-25 18:07:24.439596 INFO::Fitting model to feature number 697, F726
## 2024-06-25 18:07:24.442743 INFO::Fitting model to feature number 698, F727
## 2024-06-25 18:07:24.445906 INFO::Fitting model to feature number 699, F728
## 2024-06-25 18:07:24.449073 INFO::Fitting model to feature number 700, F729
## 2024-06-25 18:07:24.45223 INFO::Fitting model to feature number 701, F730
## 2024-06-25 18:07:24.455421 INFO::Fitting model to feature number 702, F731
## 2024-06-25 18:07:24.458617 INFO::Fitting model to feature number 703, F732
## 2024-06-25 18:07:24.461835 INFO::Fitting model to feature number 704, F733
## 2024-06-25 18:07:24.464965 INFO::Fitting model to feature number 705, F734
## 2024-06-25 18:07:24.468124 INFO::Fitting model to feature number 706, F735
## 2024-06-25 18:07:24.471277 INFO::Fitting model to feature number 707, F736
## 2024-06-25 18:07:24.474438 INFO::Fitting model to feature number 708, F737
## 2024-06-25 18:07:24.477594 INFO::Fitting model to feature number 709, F739
## 2024-06-25 18:07:24.480742 INFO::Fitting model to feature number 710, F740
## 2024-06-25 18:07:24.483857 INFO::Fitting model to feature number 711, F741
## 2024-06-25 18:07:24.48699 INFO::Fitting model to feature number 712, F742
## 2024-06-25 18:07:24.490127 INFO::Fitting model to feature number 713, F743
## 2024-06-25 18:07:24.493291 INFO::Fitting model to feature number 714, F744
## 2024-06-25 18:07:24.496475 INFO::Fitting model to feature number 715, F745
## 2024-06-25 18:07:24.499672 INFO::Fitting model to feature number 716, F746
## 2024-06-25 18:07:24.502952 INFO::Fitting model to feature number 717, F747
## 2024-06-25 18:07:24.50624 INFO::Fitting model to feature number 718, F748
## 2024-06-25 18:07:24.509495 INFO::Fitting model to feature number 719, F749
## 2024-06-25 18:07:24.512727 INFO::Fitting model to feature number 720, F750
## 2024-06-25 18:07:24.515922 INFO::Fitting model to feature number 721, F751
## 2024-06-25 18:07:24.519081 INFO::Fitting model to feature number 722, F752
## 2024-06-25 18:07:24.522259 INFO::Fitting model to feature number 723, F753
## 2024-06-25 18:07:24.525419 INFO::Fitting model to feature number 724, F754
## 2024-06-25 18:07:24.528556 INFO::Fitting model to feature number 725, F755
## 2024-06-25 18:07:24.531628 INFO::Fitting model to feature number 726, F756
## 2024-06-25 18:07:24.534768 INFO::Fitting model to feature number 727, F757
## 2024-06-25 18:07:24.537918 INFO::Fitting model to feature number 728, F758
## 2024-06-25 18:07:24.541063 INFO::Fitting model to feature number 729, F759
## 2024-06-25 18:07:24.544192 INFO::Fitting model to feature number 730, F760
## 2024-06-25 18:07:24.547352 INFO::Fitting model to feature number 731, F761
## 2024-06-25 18:07:24.55048 INFO::Fitting model to feature number 732, F762
## 2024-06-25 18:07:24.553615 INFO::Fitting model to feature number 733, F763
## 2024-06-25 18:07:24.556773 INFO::Fitting model to feature number 734, F764
## 2024-06-25 18:07:24.559901 INFO::Fitting model to feature number 735, F765
## 2024-06-25 18:07:24.563049 INFO::Fitting model to feature number 736, F766
## 2024-06-25 18:07:24.566187 INFO::Fitting model to feature number 737, F767
## 2024-06-25 18:07:24.56933 INFO::Fitting model to feature number 738, F768
## 2024-06-25 18:07:24.572372 INFO::Fitting model to feature number 739, F769
## 2024-06-25 18:07:24.5755 INFO::Fitting model to feature number 740, F770
## 2024-06-25 18:07:24.578621 INFO::Fitting model to feature number 741, F771
## 2024-06-25 18:07:24.581742 INFO::Fitting model to feature number 742, F772
## 2024-06-25 18:07:24.584863 INFO::Fitting model to feature number 743, F773
## 2024-06-25 18:07:24.58801 INFO::Fitting model to feature number 744, F774
## 2024-06-25 18:07:24.591131 INFO::Fitting model to feature number 745, F775
## 2024-06-25 18:07:24.594251 INFO::Fitting model to feature number 746, F776
## 2024-06-25 18:07:24.597363 INFO::Fitting model to feature number 747, F777
## 2024-06-25 18:07:24.600483 INFO::Fitting model to feature number 748, F778
## 2024-06-25 18:07:24.603579 INFO::Fitting model to feature number 749, F779
## 2024-06-25 18:07:24.606685 INFO::Fitting model to feature number 750, F780
## 2024-06-25 18:07:24.609799 INFO::Fitting model to feature number 751, F781
## 2024-06-25 18:07:24.612915 INFO::Fitting model to feature number 752, F782
## 2024-06-25 18:07:24.616023 INFO::Fitting model to feature number 753, F783
## 2024-06-25 18:07:24.619136 INFO::Fitting model to feature number 754, F784
## 2024-06-25 18:07:24.622245 INFO::Fitting model to feature number 755, F785
## 2024-06-25 18:07:24.625377 INFO::Fitting model to feature number 756, F786
## 2024-06-25 18:07:24.628496 INFO::Fitting model to feature number 757, F787
## 2024-06-25 18:07:24.631603 INFO::Fitting model to feature number 758, F788
## 2024-06-25 18:07:24.634742 INFO::Fitting model to feature number 759, F789
## 2024-06-25 18:07:24.637887 INFO::Fitting model to feature number 760, F790
## 2024-06-25 18:07:24.641057 INFO::Fitting model to feature number 761, F791
## 2024-06-25 18:07:24.644219 INFO::Fitting model to feature number 762, F792
## 2024-06-25 18:07:24.647385 INFO::Fitting model to feature number 763, F793
## 2024-06-25 18:07:24.650507 INFO::Fitting model to feature number 764, F794
## 2024-06-25 18:07:24.653629 INFO::Fitting model to feature number 765, F795
## 2024-06-25 18:07:24.656745 INFO::Fitting model to feature number 766, F796
## 2024-06-25 18:07:24.659876 INFO::Fitting model to feature number 767, F797
## 2024-06-25 18:07:24.663001 INFO::Fitting model to feature number 768, F798
## 2024-06-25 18:07:24.666127 INFO::Fitting model to feature number 769, F799
## 2024-06-25 18:07:24.669243 INFO::Fitting model to feature number 770, F800
## 2024-06-25 18:07:24.672343 INFO::Fitting model to feature number 771, F801
## 2024-06-25 18:07:24.675452 INFO::Fitting model to feature number 772, F802
## 2024-06-25 18:07:24.67856 INFO::Fitting model to feature number 773, F803
## 2024-06-25 18:07:24.681675 INFO::Fitting model to feature number 774, F804
## 2024-06-25 18:07:24.684797 INFO::Fitting model to feature number 775, F805
## 2024-06-25 18:07:24.6879 INFO::Fitting model to feature number 776, F806
## 2024-06-25 18:07:24.69102 INFO::Fitting model to feature number 777, F808
## 2024-06-25 18:07:24.694147 INFO::Fitting model to feature number 778, F809
## 2024-06-25 18:07:24.697273 INFO::Fitting model to feature number 779, F810
## 2024-06-25 18:07:24.700368 INFO::Fitting model to feature number 780, F811
## 2024-06-25 18:07:24.703501 INFO::Fitting model to feature number 781, F812
## 2024-06-25 18:07:24.706663 INFO::Fitting model to feature number 782, F813
## 2024-06-25 18:07:24.709732 INFO::Fitting model to feature number 783, F814
## 2024-06-25 18:07:24.712864 INFO::Fitting model to feature number 784, F815
## 2024-06-25 18:07:24.716 INFO::Fitting model to feature number 785, F816
## 2024-06-25 18:07:24.719139 INFO::Fitting model to feature number 786, F817
## 2024-06-25 18:07:24.722268 INFO::Fitting model to feature number 787, F818
## 2024-06-25 18:07:24.725397 INFO::Fitting model to feature number 788, F819
## 2024-06-25 18:07:24.728543 INFO::Fitting model to feature number 789, F820
## 2024-06-25 18:07:24.731669 INFO::Fitting model to feature number 790, F821
## 2024-06-25 18:07:24.734807 INFO::Fitting model to feature number 791, F822
## 2024-06-25 18:07:24.737942 INFO::Fitting model to feature number 792, F823
## 2024-06-25 18:07:24.741083 INFO::Fitting model to feature number 793, F824
## 2024-06-25 18:07:24.744219 INFO::Fitting model to feature number 794, F825
## 2024-06-25 18:07:24.747338 INFO::Fitting model to feature number 795, F826
## 2024-06-25 18:07:24.750469 INFO::Fitting model to feature number 796, F827
## 2024-06-25 18:07:24.753605 INFO::Fitting model to feature number 797, F828
## 2024-06-25 18:07:24.756723 INFO::Fitting model to feature number 798, F829
## 2024-06-25 18:07:24.759829 INFO::Fitting model to feature number 799, F830
## 2024-06-25 18:07:24.762953 INFO::Fitting model to feature number 800, F831
## 2024-06-25 18:07:24.766132 INFO::Fitting model to feature number 801, F832
## 2024-06-25 18:07:24.769276 INFO::Fitting model to feature number 802, F833
## 2024-06-25 18:07:24.772415 INFO::Fitting model to feature number 803, F834
## 2024-06-25 18:07:24.775556 INFO::Fitting model to feature number 804, F835
## 2024-06-25 18:07:24.778715 INFO::Fitting model to feature number 805, F836
## 2024-06-25 18:07:24.781884 INFO::Fitting model to feature number 806, F837
## 2024-06-25 18:07:24.785081 INFO::Fitting model to feature number 807, F838
## 2024-06-25 18:07:24.788275 INFO::Fitting model to feature number 808, F839
## 2024-06-25 18:07:24.791482 INFO::Fitting model to feature number 809, F840
## 2024-06-25 18:07:24.794665 INFO::Fitting model to feature number 810, F841
## 2024-06-25 18:07:24.797815 INFO::Fitting model to feature number 811, F842
## 2024-06-25 18:07:24.800916 INFO::Fitting model to feature number 812, F843
## 2024-06-25 18:07:24.804063 INFO::Fitting model to feature number 813, F844
## 2024-06-25 18:07:24.807245 INFO::Fitting model to feature number 814, F845
## 2024-06-25 18:07:24.810412 INFO::Fitting model to feature number 815, F846
## 2024-06-25 18:07:24.813529 INFO::Fitting model to feature number 816, F847
## 2024-06-25 18:07:24.816654 INFO::Fitting model to feature number 817, F848
## 2024-06-25 18:07:24.819778 INFO::Fitting model to feature number 818, F849
## 2024-06-25 18:07:24.822963 INFO::Fitting model to feature number 819, F850
## 2024-06-25 18:07:24.826164 INFO::Fitting model to feature number 820, F851
## 2024-06-25 18:07:24.829332 INFO::Fitting model to feature number 821, F852
## 2024-06-25 18:07:24.832492 INFO::Fitting model to feature number 822, F853
## 2024-06-25 18:07:24.835641 INFO::Fitting model to feature number 823, F854
## 2024-06-25 18:07:24.838799 INFO::Fitting model to feature number 824, F855
## 2024-06-25 18:07:24.841979 INFO::Fitting model to feature number 825, F856
## 2024-06-25 18:07:24.845145 INFO::Fitting model to feature number 826, F857
## 2024-06-25 18:07:24.848298 INFO::Fitting model to feature number 827, F858
## 2024-06-25 18:07:24.851537 INFO::Fitting model to feature number 828, F859
## 2024-06-25 18:07:24.854734 INFO::Fitting model to feature number 829, F860
## 2024-06-25 18:07:24.857986 INFO::Fitting model to feature number 830, F861
## 2024-06-25 18:07:24.861215 INFO::Fitting model to feature number 831, F862
## 2024-06-25 18:07:24.86441 INFO::Fitting model to feature number 832, F863
## 2024-06-25 18:07:24.867591 INFO::Fitting model to feature number 833, F864
## 2024-06-25 18:07:24.870775 INFO::Fitting model to feature number 834, F865
## 2024-06-25 18:07:24.874005 INFO::Fitting model to feature number 835, F866
## 2024-06-25 18:07:24.877243 INFO::Fitting model to feature number 836, F867
## 2024-06-25 18:07:24.880458 INFO::Fitting model to feature number 837, F868
## 2024-06-25 18:07:24.883699 INFO::Fitting model to feature number 838, F869
## 2024-06-25 18:07:24.88696 INFO::Fitting model to feature number 839, F870
## 2024-06-25 18:07:24.89019 INFO::Fitting model to feature number 840, F871
## 2024-06-25 18:07:24.893391 INFO::Fitting model to feature number 841, F872
## 2024-06-25 18:07:24.896618 INFO::Fitting model to feature number 842, F873
## 2024-06-25 18:07:24.899834 INFO::Fitting model to feature number 843, F874
## 2024-06-25 18:07:24.903057 INFO::Fitting model to feature number 844, F875
## 2024-06-25 18:07:24.906285 INFO::Fitting model to feature number 845, F876
## 2024-06-25 18:07:24.909506 INFO::Fitting model to feature number 846, F877
## 2024-06-25 18:07:24.912735 INFO::Fitting model to feature number 847, F878
## 2024-06-25 18:07:24.915921 INFO::Fitting model to feature number 848, F879
## 2024-06-25 18:07:24.919144 INFO::Fitting model to feature number 849, F880
## 2024-06-25 18:07:24.922361 INFO::Fitting model to feature number 850, F881
## 2024-06-25 18:07:24.925581 INFO::Fitting model to feature number 851, F882
## 2024-06-25 18:07:24.928793 INFO::Fitting model to feature number 852, F883
## 2024-06-25 18:07:24.931983 INFO::Fitting model to feature number 853, F884
## 2024-06-25 18:07:24.935208 INFO::Fitting model to feature number 854, F885
## 2024-06-25 18:07:24.938422 INFO::Fitting model to feature number 855, F886
## 2024-06-25 18:07:24.94163 INFO::Fitting model to feature number 856, F887
## 2024-06-25 18:07:24.944838 INFO::Fitting model to feature number 857, F888
## 2024-06-25 18:07:24.94805 INFO::Fitting model to feature number 858, F889
## 2024-06-25 18:07:24.951264 INFO::Fitting model to feature number 859, F890
## 2024-06-25 18:07:24.954482 INFO::Fitting model to feature number 860, F891
## 2024-06-25 18:07:24.957712 INFO::Fitting model to feature number 861, F892
## 2024-06-25 18:07:24.960945 INFO::Fitting model to feature number 862, F893
## 2024-06-25 18:07:24.964177 INFO::Fitting model to feature number 863, F894
## 2024-06-25 18:07:24.967403 INFO::Fitting model to feature number 864, F895
## 2024-06-25 18:07:24.970623 INFO::Fitting model to feature number 865, F896
## 2024-06-25 18:07:24.973846 INFO::Fitting model to feature number 866, F897
## 2024-06-25 18:07:24.977077 INFO::Fitting model to feature number 867, F898
## 2024-06-25 18:07:24.980287 INFO::Fitting model to feature number 868, F899
## 2024-06-25 18:07:24.983497 INFO::Fitting model to feature number 869, F900
## 2024-06-25 18:07:25.149547 INFO::Counting total values for each feature
## 2024-06-25 18:07:25.264309 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2024-06-25 18:07:25.40742 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2024-06-25 18:07:25.555133 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2024-06-25 18:07:25.69946 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2024-06-25 18:07:25.747888 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2024-06-25 18:07:25.789047 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2024-06-25 18:07:25.809987 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2024-06-25 18:07:25.819326 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2024-06-25 18:07:25.836498 INFO::Plotting associations from most to least significant, grouped by metadata
## 2024-06-25 18:07:25.837549 INFO::Plotting data for metadata number 1, diagnosis
## 2024-06-25 18:07:25.882455 INFO::Creating boxplot for categorical data, diagnosis vs F504
## 2024-06-25 18:07:26.200527 INFO::Creating boxplot for categorical data, diagnosis vs F859
## 2024-06-25 18:07:26.471078 INFO::Creating boxplot for categorical data, diagnosis vs F533
## 2024-06-25 18:07:26.644035 INFO::Creating boxplot for categorical data, diagnosis vs F587
## 2024-06-25 18:07:26.804449 INFO::Creating boxplot for categorical data, diagnosis vs F584
## 2024-06-25 18:07:26.971149 INFO::Creating boxplot for categorical data, diagnosis vs F197
## 2024-06-25 18:07:27.134125 INFO::Creating boxplot for categorical data, diagnosis vs F380
## 2024-06-25 18:07:27.30771 INFO::Creating boxplot for categorical data, diagnosis vs F829
## 2024-06-25 18:07:27.465118 INFO::Creating boxplot for categorical data, diagnosis vs F664
## 2024-06-25 18:07:27.626682 INFO::Creating boxplot for categorical data, diagnosis vs F93
## 2024-06-25 18:07:27.78829 INFO::Creating boxplot for categorical data, diagnosis vs F15
## 2024-06-25 18:07:27.948785 INFO::Creating boxplot for categorical data, diagnosis vs F881
## 2024-06-25 18:07:28.107769 INFO::Creating boxplot for categorical data, diagnosis vs F806
## 2024-06-25 18:07:28.28457 INFO::Creating boxplot for categorical data, diagnosis vs F78
## 2024-06-25 18:07:28.440771 INFO::Creating boxplot for categorical data, diagnosis vs F189
## 2024-06-25 18:07:28.597916 INFO::Creating boxplot for categorical data, diagnosis vs F369
## 2024-06-25 18:07:28.764823 INFO::Creating boxplot for categorical data, diagnosis vs F623
## 2024-06-25 18:07:28.934476 INFO::Creating boxplot for categorical data, diagnosis vs F710
## 2024-06-25 18:07:29.11116 INFO::Creating boxplot for categorical data, diagnosis vs F851
## 2024-06-25 18:07:29.267538 INFO::Creating boxplot for categorical data, diagnosis vs F257
## 2024-06-25 18:07:29.423516 INFO::Creating boxplot for categorical data, diagnosis vs F330
## 2024-06-25 18:07:29.582601 INFO::Creating boxplot for categorical data, diagnosis vs F344
## 2024-06-25 18:07:29.741012 INFO::Creating boxplot for categorical data, diagnosis vs F696
## 2024-06-25 18:07:29.898073 INFO::Creating boxplot for categorical data, diagnosis vs F741
## 2024-06-25 18:07:30.063997 INFO::Creating boxplot for categorical data, diagnosis vs F509
## 2024-06-25 18:07:30.219725 INFO::Creating boxplot for categorical data, diagnosis vs F479
## 2024-06-25 18:07:30.377485 INFO::Creating boxplot for categorical data, diagnosis vs F550
## 2024-06-25 18:07:30.537202 INFO::Creating boxplot for categorical data, diagnosis vs F640
## 2024-06-25 18:07:30.695692 INFO::Creating boxplot for categorical data, diagnosis vs F281
## 2024-06-25 18:07:30.864518 INFO::Creating boxplot for categorical data, diagnosis vs F80
## 2024-06-25 18:07:31.018965 INFO::Creating boxplot for categorical data, diagnosis vs F285
## 2024-06-25 18:07:31.1747 INFO::Creating boxplot for categorical data, diagnosis vs F531
## 2024-06-25 18:07:31.332912 INFO::Creating boxplot for categorical data, diagnosis vs F737
## 2024-06-25 18:07:31.491772 INFO::Creating boxplot for categorical data, diagnosis vs F875
## 2024-06-25 18:07:31.657062 INFO::Creating boxplot for categorical data, diagnosis vs F864
## 2024-06-25 18:07:31.831815 INFO::Creating boxplot for categorical data, diagnosis vs F379
## 2024-06-25 18:07:31.987737 INFO::Creating boxplot for categorical data, diagnosis vs F190
## 2024-06-25 18:07:32.145574 INFO::Creating boxplot for categorical data, diagnosis vs F4
## 2024-06-25 18:07:32.307441 INFO::Creating boxplot for categorical data, diagnosis vs F591
## 2024-06-25 18:07:32.467036 INFO::Creating boxplot for categorical data, diagnosis vs F773
## 2024-06-25 18:07:32.633646 INFO::Creating boxplot for categorical data, diagnosis vs F283
## 2024-06-25 18:07:32.787184 INFO::Creating boxplot for categorical data, diagnosis vs F233
## 2024-06-25 18:07:32.946449 INFO::Creating boxplot for categorical data, diagnosis vs F420
## 2024-06-25 18:07:33.105354 INFO::Creating boxplot for categorical data, diagnosis vs F5
## 2024-06-25 18:07:33.266382 INFO::Creating boxplot for categorical data, diagnosis vs F137
## 2024-06-25 18:07:33.436979 INFO::Creating boxplot for categorical data, diagnosis vs F215
## 2024-06-25 18:07:33.592652 INFO::Creating boxplot for categorical data, diagnosis vs F489
## 2024-06-25 18:07:33.750271 INFO::Creating boxplot for categorical data, diagnosis vs F220
## 2024-06-25 18:07:33.91081 INFO::Creating boxplot for categorical data, diagnosis vs F691
## 2024-06-25 18:07:34.070411 INFO::Creating boxplot for categorical data, diagnosis vs F381
## 2024-06-25 18:07:34.233033 INFO::Creating boxplot for categorical data, diagnosis vs F539
## 2024-06-25 18:07:34.403198 INFO::Creating boxplot for categorical data, diagnosis vs F490
## 2024-06-25 18:07:34.558946 INFO::Creating boxplot for categorical data, diagnosis vs F832
## 2024-06-25 18:07:34.720108 INFO::Creating boxplot for categorical data, diagnosis vs F396
## 2024-06-25 18:07:34.879945 INFO::Creating boxplot for categorical data, diagnosis vs F528
## 2024-06-25 18:07:35.047002 INFO::Creating boxplot for categorical data, diagnosis vs F234
## 2024-06-25 18:07:35.227447 INFO::Creating boxplot for categorical data, diagnosis vs F178
## 2024-06-25 18:07:35.387351 INFO::Creating boxplot for categorical data, diagnosis vs F761
## 2024-06-25 18:07:35.559522 INFO::Creating boxplot for categorical data, diagnosis vs F2
## 2024-06-25 18:07:35.723077 INFO::Creating boxplot for categorical data, diagnosis vs F260
## 2024-06-25 18:07:35.882275 INFO::Creating boxplot for categorical data, diagnosis vs F734
## 2024-06-25 18:07:36.046316 INFO::Creating boxplot for categorical data, diagnosis vs F429
## 2024-06-25 18:07:36.217146 INFO::Creating boxplot for categorical data, diagnosis vs F630
## 2024-06-25 18:07:36.376038 INFO::Creating boxplot for categorical data, diagnosis vs F817
## 2024-06-25 18:07:36.537522 INFO::Creating boxplot for categorical data, diagnosis vs F847
## 2024-06-25 18:07:36.699839 INFO::Creating boxplot for categorical data, diagnosis vs F896
## 2024-06-25 18:07:36.858629 INFO::Creating boxplot for categorical data, diagnosis vs F81
## 2024-06-25 18:07:37.02309 INFO::Creating boxplot for categorical data, diagnosis vs F110
## 2024-06-25 18:07:37.175867 INFO::Creating boxplot for categorical data, diagnosis vs F3
## 2024-06-25 18:07:37.332919 INFO::Creating boxplot for categorical data, diagnosis vs F33
## 2024-06-25 18:07:37.493088 INFO::Creating boxplot for categorical data, diagnosis vs F270
## 2024-06-25 18:07:37.655271 INFO::Creating boxplot for categorical data, diagnosis vs F278
## 2024-06-25 18:07:37.824302 INFO::Creating boxplot for categorical data, diagnosis vs F264
## 2024-06-25 18:07:37.978715 INFO::Creating boxplot for categorical data, diagnosis vs F90
## 2024-06-25 18:07:38.132572 INFO::Creating boxplot for categorical data, diagnosis vs F403
## 2024-06-25 18:07:38.293153 INFO::Creating boxplot for categorical data, diagnosis vs F727
## 2024-06-25 18:07:38.465295 INFO::Creating boxplot for categorical data, diagnosis vs F394
## 2024-06-25 18:07:38.650492 INFO::Creating boxplot for categorical data, diagnosis vs F800
## 2024-06-25 18:07:38.818746 INFO::Creating boxplot for categorical data, diagnosis vs F439
## 2024-06-25 18:07:38.982439 INFO::Creating boxplot for categorical data, diagnosis vs F554
## 2024-06-25 18:07:39.14649 INFO::Creating boxplot for categorical data, diagnosis vs F559
## 2024-06-25 18:07:39.305572 INFO::Creating boxplot for categorical data, diagnosis vs F548
## 2024-06-25 18:07:39.467847 INFO::Creating boxplot for categorical data, diagnosis vs F794
## 2024-06-25 18:07:39.634904 INFO::Creating boxplot for categorical data, diagnosis vs F45
## 2024-06-25 18:07:39.789925 INFO::Creating boxplot for categorical data, diagnosis vs F158
## 2024-06-25 18:07:39.949717 INFO::Creating boxplot for categorical data, diagnosis vs F477
## 2024-06-25 18:07:40.109065 INFO::Creating boxplot for categorical data, diagnosis vs F1
## 2024-06-25 18:07:40.26555 INFO::Creating boxplot for categorical data, diagnosis vs F862
## 2024-06-25 18:07:40.432247 INFO::Creating boxplot for categorical data, diagnosis vs F803
## 2024-06-25 18:07:40.584499 INFO::Creating boxplot for categorical data, diagnosis vs F751
## 2024-06-25 18:07:40.738033 INFO::Creating boxplot for categorical data, diagnosis vs F98
## 2024-06-25 18:07:40.894006 INFO::Creating boxplot for categorical data, diagnosis vs F22
## 2024-06-25 18:07:41.050613 INFO::Creating boxplot for categorical data, diagnosis vs F625
## 2024-06-25 18:07:41.219866 INFO::Creating boxplot for categorical data, diagnosis vs F206
## 2024-06-25 18:07:41.37323 INFO::Creating boxplot for categorical data, diagnosis vs F779
## 2024-06-25 18:07:41.524447 INFO::Creating boxplot for categorical data, diagnosis vs F532
## 2024-06-25 18:07:41.6794 INFO::Creating boxplot for categorical data, diagnosis vs F676
## 2024-06-25 18:07:41.85338 INFO::Creating boxplot for categorical data, diagnosis vs F644
## 2024-06-25 18:07:42.029293 INFO::Creating boxplot for categorical data, diagnosis vs F7
## 2024-06-25 18:07:42.20019 INFO::Creating boxplot for categorical data, diagnosis vs F596
## 2024-06-25 18:07:42.355546 INFO::Creating boxplot for categorical data, diagnosis vs F250
## 2024-06-25 18:07:42.513579 INFO::Creating boxplot for categorical data, diagnosis vs F462
## 2024-06-25 18:07:42.677025 INFO::Creating boxplot for categorical data, diagnosis vs F516
## 2024-06-25 18:07:42.836064 INFO::Creating boxplot for categorical data, diagnosis vs F659
## 2024-06-25 18:07:43.003718 INFO::Creating boxplot for categorical data, diagnosis vs F663
## 2024-06-25 18:07:43.159107 INFO::Creating boxplot for categorical data, diagnosis vs F837
## 2024-06-25 18:07:43.316828 INFO::Creating boxplot for categorical data, diagnosis vs F138
## 2024-06-25 18:07:43.479146 INFO::Creating boxplot for categorical data, diagnosis vs F445
## 2024-06-25 18:07:43.638146 INFO::Creating boxplot for categorical data, diagnosis vs F697
## 2024-06-25 18:07:43.806581 INFO::Creating boxplot for categorical data, diagnosis vs F225
## 2024-06-25 18:07:43.958955 INFO::Creating boxplot for categorical data, diagnosis vs F148
## 2024-06-25 18:07:44.113207 INFO::Creating boxplot for categorical data, diagnosis vs F448
## 2024-06-25 18:07:44.269869 INFO::Creating boxplot for categorical data, diagnosis vs F91
## 2024-06-25 18:07:44.429953 INFO::Creating boxplot for categorical data, diagnosis vs F123
## 2024-06-25 18:07:44.654826 INFO::Creating boxplot for categorical data, diagnosis vs F665
## 2024-06-25 18:07:44.810696 INFO::Creating boxplot for categorical data, diagnosis vs F845
## 2024-06-25 18:07:44.966109 INFO::Creating boxplot for categorical data, diagnosis vs F331
## 2024-06-25 18:07:45.125398 INFO::Creating boxplot for categorical data, diagnosis vs F361
## 2024-06-25 18:07:45.285108 INFO::Creating boxplot for categorical data, diagnosis vs F421
## 2024-06-25 18:07:45.444872 INFO::Creating boxplot for categorical data, diagnosis vs F277
## 2024-06-25 18:07:45.622459 INFO::Creating boxplot for categorical data, diagnosis vs F307
## 2024-06-25 18:07:45.783893 INFO::Creating boxplot for categorical data, diagnosis vs F503
## 2024-06-25 18:07:45.939768 INFO::Creating boxplot for categorical data, diagnosis vs F34
## 2024-06-25 18:07:46.099695 INFO::Creating boxplot for categorical data, diagnosis vs F649
## 2024-06-25 18:07:46.265938 INFO::Creating boxplot for categorical data, diagnosis vs F825
## 2024-06-25 18:07:46.449945 INFO::Creating boxplot for categorical data, diagnosis vs F298
## 2024-06-25 18:07:46.611065 INFO::Creating boxplot for categorical data, diagnosis vs F461
## 2024-06-25 18:07:46.766293 INFO::Creating boxplot for categorical data, diagnosis vs F242
## 2024-06-25 18:07:46.924969 INFO::Creating boxplot for categorical data, diagnosis vs F375
## 2024-06-25 18:07:47.08347 INFO::Creating boxplot for categorical data, diagnosis vs F648
## 2024-06-25 18:07:47.247271 INFO::Creating boxplot for categorical data, diagnosis vs F724
## 2024-06-25 18:07:47.420587 INFO::Creating boxplot for categorical data, diagnosis vs F678
## 2024-06-25 18:07:47.578278 INFO::Creating boxplot for categorical data, diagnosis vs F290
## 2024-06-25 18:07:47.736778 INFO::Creating boxplot for categorical data, diagnosis vs F743
## 2024-06-25 18:07:47.896807 INFO::Creating boxplot for categorical data, diagnosis vs F495
## 2024-06-25 18:07:48.056649 INFO::Creating boxplot for categorical data, diagnosis vs F261
## 2024-06-25 18:07:48.23355 INFO::Creating boxplot for categorical data, diagnosis vs F43
## 2024-06-25 18:07:48.392188 INFO::Creating boxplot for categorical data, diagnosis vs F714
## 2024-06-25 18:07:48.551423 INFO::Creating boxplot for categorical data, diagnosis vs F131
## 2024-06-25 18:07:48.711639 INFO::Creating boxplot for categorical data, diagnosis vs F150
## 2024-06-25 18:07:48.87253 INFO::Creating boxplot for categorical data, diagnosis vs F651
## 2024-06-25 18:07:49.037055 INFO::Creating boxplot for categorical data, diagnosis vs F798
## 2024-06-25 18:07:49.21161 INFO::Creating boxplot for categorical data, diagnosis vs F289
## 2024-06-25 18:07:49.366476 INFO::Creating boxplot for categorical data, diagnosis vs F661
## 2024-06-25 18:07:49.524099 INFO::Creating boxplot for categorical data, diagnosis vs F199
## 2024-06-25 18:07:49.682539 INFO::Creating boxplot for categorical data, diagnosis vs F406
## 2024-06-25 18:07:49.842892 INFO::Creating boxplot for categorical data, diagnosis vs F139
## 2024-06-25 18:07:50.021607 INFO::Creating boxplot for categorical data, diagnosis vs F506
## 2024-06-25 18:07:50.18031 INFO::Creating boxplot for categorical data, diagnosis vs F552
## 2024-06-25 18:07:50.342678 INFO::Creating boxplot for categorical data, diagnosis vs F94
## 2024-06-25 18:07:50.50421 INFO::Creating boxplot for categorical data, diagnosis vs F430
## 2024-06-25 18:07:50.671202 INFO::Creating boxplot for categorical data, diagnosis vs F639
## 2024-06-25 18:07:50.853119 INFO::Creating boxplot for categorical data, diagnosis vs F500
## 2024-06-25 18:07:51.016248 INFO::Creating boxplot for categorical data, diagnosis vs F609
## 2024-06-25 18:07:51.180766 INFO::Creating boxplot for categorical data, diagnosis vs F306
## 2024-06-25 18:07:51.351622 INFO::Creating boxplot for categorical data, diagnosis vs F507
## 2024-06-25 18:07:51.513919 INFO::Creating boxplot for categorical data, diagnosis vs F671
## 2024-06-25 18:07:51.675387 INFO::Creating boxplot for categorical data, diagnosis vs F894
## 2024-06-25 18:07:51.85562 INFO::Creating boxplot for categorical data, diagnosis vs F345
## 2024-06-25 18:07:52.015327 INFO::Creating boxplot for categorical data, diagnosis vs F801
## 2024-06-25 18:07:52.175538 INFO::Creating boxplot for categorical data, diagnosis vs F194
## 2024-06-25 18:07:52.340658 INFO::Creating boxplot for categorical data, diagnosis vs F195
## 2024-06-25 18:07:52.501878 INFO::Creating boxplot for categorical data, diagnosis vs F119
## 2024-06-25 18:07:52.681336 INFO::Creating boxplot for categorical data, diagnosis vs F120
## 2024-06-25 18:07:52.844295 INFO::Creating boxplot for categorical data, diagnosis vs F231
## 2024-06-25 18:07:53.005251 INFO::Creating boxplot for categorical data, diagnosis vs F311
## 2024-06-25 18:07:53.165142 INFO::Creating boxplot for categorical data, diagnosis vs F646
## 2024-06-25 18:07:53.327577 INFO::Creating boxplot for categorical data, diagnosis vs F814
## 2024-06-25 18:07:53.490231 INFO::Creating boxplot for categorical data, diagnosis vs F510
## 2024-06-25 18:07:53.669741 INFO::Creating boxplot for categorical data, diagnosis vs F398
## 2024-06-25 18:07:53.824323 INFO::Creating boxplot for categorical data, diagnosis vs F60
## 2024-06-25 18:07:53.983063 INFO::Creating boxplot for categorical data, diagnosis vs F153
## 2024-06-25 18:07:54.145239 INFO::Creating boxplot for categorical data, diagnosis vs F858
## 2024-06-25 18:07:54.305752 INFO::Creating boxplot for categorical data, diagnosis vs F775
## 2024-06-25 18:07:54.484271 INFO::Creating boxplot for categorical data, diagnosis vs F684
## 2024-06-25 18:07:54.64524 INFO::Creating boxplot for categorical data, diagnosis vs F384
## 2024-06-25 18:07:54.803061 INFO::Creating boxplot for categorical data, diagnosis vs F134
## 2024-06-25 18:07:54.97429 INFO::Creating boxplot for categorical data, diagnosis vs F670
## 2024-06-25 18:07:55.144508 INFO::Creating boxplot for categorical data, diagnosis vs F632
## 2024-06-25 18:07:55.347566 INFO::Creating boxplot for categorical data, diagnosis vs F721
## 2024-06-25 18:07:55.519017 INFO::Creating boxplot for categorical data, diagnosis vs F700
## 2024-06-25 18:07:55.681073 INFO::Creating boxplot for categorical data, diagnosis vs F376
## 2024-06-25 18:07:55.848538 INFO::Creating boxplot for categorical data, diagnosis vs F301
## 2024-06-25 18:07:56.008914 INFO::Creating boxplot for categorical data, diagnosis vs F27
## 2024-06-25 18:07:56.183237 INFO::Creating boxplot for categorical data, diagnosis vs F280
## 2024-06-25 18:07:56.348854 INFO::Creating boxplot for categorical data, diagnosis vs F391
## 2024-06-25 18:07:56.507057 INFO::Creating boxplot for categorical data, diagnosis vs F725
## 2024-06-25 18:07:56.669847 INFO::Creating boxplot for categorical data, diagnosis vs F186
## 2024-06-25 18:07:56.837321 INFO::Creating boxplot for categorical data, diagnosis vs F481
## 2024-06-25 18:07:57.00608 INFO::Creating boxplot for categorical data, diagnosis vs F333
## 2024-06-25 18:07:57.200832 INFO::Creating boxplot for categorical data, diagnosis vs F720
## 2024-06-25 18:07:57.363277 INFO::Creating boxplot for categorical data, diagnosis vs F520
## 2024-06-25 18:07:57.528226 INFO::Creating boxplot for categorical data, diagnosis vs F129
## 2024-06-25 18:07:57.691399 INFO::Creating boxplot for categorical data, diagnosis vs F204
## 2024-06-25 18:07:57.855062 INFO::Creating boxplot for categorical data, diagnosis vs F259
## 2024-06-25 18:07:58.03531 INFO::Creating boxplot for categorical data, diagnosis vs F831
## 2024-06-25 18:07:58.197345 INFO::Creating boxplot for categorical data, diagnosis vs F891
## 2024-06-25 18:07:58.359505 INFO::Creating boxplot for categorical data, diagnosis vs F262
## 2024-06-25 18:07:58.521406 INFO::Creating boxplot for categorical data, diagnosis vs F592
## 2024-06-25 18:07:58.68171 INFO::Creating boxplot for categorical data, diagnosis vs F343
## 2024-06-25 18:07:58.865455 INFO::Creating boxplot for categorical data, diagnosis vs F505
## 2024-06-25 18:07:59.029042 INFO::Creating boxplot for categorical data, diagnosis vs F622
## 2024-06-25 18:07:59.190956 INFO::Creating boxplot for categorical data, diagnosis vs F348
## 2024-06-25 18:07:59.371458 INFO::Creating boxplot for categorical data, diagnosis vs F133
## 2024-06-25 18:07:59.552628 INFO::Creating boxplot for categorical data, diagnosis vs F371
## 2024-06-25 18:07:59.734744 INFO::Creating boxplot for categorical data, diagnosis vs F113
## 2024-06-25 18:07:59.914868 INFO::Creating boxplot for categorical data, diagnosis vs F336
## 2024-06-25 18:08:00.071909 INFO::Creating boxplot for categorical data, diagnosis vs F399
## 2024-06-25 18:08:00.232748 INFO::Creating boxplot for categorical data, diagnosis vs F416
## 2024-06-25 18:08:00.400044 INFO::Creating boxplot for categorical data, diagnosis vs F657
## 2024-06-25 18:08:00.563137 INFO::Creating boxplot for categorical data, diagnosis vs F241
## 2024-06-25 18:08:00.743482 INFO::Creating boxplot for categorical data, diagnosis vs F95
## 2024-06-25 18:08:00.902452 INFO::Creating boxplot for categorical data, diagnosis vs F128
## 2024-06-25 18:08:01.06084 INFO::Creating boxplot for categorical data, diagnosis vs F595
## 2024-06-25 18:08:01.225068 INFO::Creating boxplot for categorical data, diagnosis vs F428
## 2024-06-25 18:08:01.388585 INFO::Creating boxplot for categorical data, diagnosis vs F796
## 2024-06-25 18:08:01.57232 INFO::Creating boxplot for categorical data, diagnosis vs F709
## 2024-06-25 18:08:01.731918 INFO::Creating boxplot for categorical data, diagnosis vs F602
## 2024-06-25 18:08:01.890956 INFO::Creating boxplot for categorical data, diagnosis vs F293
## 2024-06-25 18:08:02.051663 INFO::Creating boxplot for categorical data, diagnosis vs F867
## 2024-06-25 18:08:02.211857 INFO::Creating boxplot for categorical data, diagnosis vs F108
## 2024-06-25 18:08:02.392139 INFO::Creating boxplot for categorical data, diagnosis vs F846
## 2024-06-25 18:08:02.55167 INFO::Creating boxplot for categorical data, diagnosis vs F633
## 2024-06-25 18:08:02.710231 INFO::Creating boxplot for categorical data, diagnosis vs F564
## 2024-06-25 18:08:02.876188 INFO::Creating boxplot for categorical data, diagnosis vs F183
## 2024-06-25 18:08:03.041343 INFO::Creating boxplot for categorical data, diagnosis vs F647
## 2024-06-25 18:08:03.90843 INFO::Creating boxplot for categorical data, diagnosis vs F288
## 2024-06-25 18:08:04.063749 INFO::Creating boxplot for categorical data, diagnosis vs F159
## 2024-06-25 18:08:04.219342 INFO::Creating boxplot for categorical data, diagnosis vs F638
## 2024-06-25 18:08:04.376146 INFO::Creating boxplot for categorical data, diagnosis vs F484
## 2024-06-25 18:08:04.538579 INFO::Creating boxplot for categorical data, diagnosis vs F20
## 2024-06-25 18:08:04.70503 INFO::Creating boxplot for categorical data, diagnosis vs F19
## 2024-06-25 18:08:04.872135 INFO::Creating boxplot for categorical data, diagnosis vs F897
## 2024-06-25 18:08:05.031625 INFO::Creating boxplot for categorical data, diagnosis vs F442
## 2024-06-25 18:08:05.19909 INFO::Creating boxplot for categorical data, diagnosis vs F372
## 2024-06-25 18:08:05.358462 INFO::Creating boxplot for categorical data, diagnosis vs F771
## 2024-06-25 18:08:05.516325 INFO::Creating boxplot for categorical data, diagnosis vs F370
## 2024-06-25 18:08:05.690151 INFO::Creating boxplot for categorical data, diagnosis vs F620
## 2024-06-25 18:08:05.844001 INFO::Creating boxplot for categorical data, diagnosis vs F753
## 2024-06-25 18:08:05.999201 INFO::Creating boxplot for categorical data, diagnosis vs F568
## 2024-06-25 18:08:06.158394 INFO::Creating boxplot for categorical data, diagnosis vs F312
## 2024-06-25 18:08:06.319964 INFO::Creating boxplot for categorical data, diagnosis vs F485
## 2024-06-25 18:08:06.482794 INFO::Creating boxplot for categorical data, diagnosis vs F627
## 2024-06-25 18:08:06.649481 INFO::Creating boxplot for categorical data, diagnosis vs F72
## 2024-06-25 18:08:06.813323 INFO::Creating boxplot for categorical data, diagnosis vs F575
## 2024-06-25 18:08:06.969812 INFO::Creating boxplot for categorical data, diagnosis vs F332
## 2024-06-25 18:08:07.132626 INFO::Creating boxplot for categorical data, diagnosis vs F674
## 2024-06-25 18:08:07.293522 INFO::Creating boxplot for categorical data, diagnosis vs F537
## 2024-06-25 18:08:07.464955 INFO::Creating boxplot for categorical data, diagnosis vs F839
## 2024-06-25 18:08:07.623255 INFO::Creating boxplot for categorical data, diagnosis vs F715
## 2024-06-25 18:08:07.779862 INFO::Creating boxplot for categorical data, diagnosis vs F768
## 2024-06-25 18:08:07.938357 INFO::Creating boxplot for categorical data, diagnosis vs F202
## 2024-06-25 18:08:08.1006 INFO::Creating boxplot for categorical data, diagnosis vs F756
## 2024-06-25 18:08:08.263534 INFO::Creating boxplot for categorical data, diagnosis vs F536
## 2024-06-25 18:08:08.439268 INFO::Creating boxplot for categorical data, diagnosis vs F677
## 2024-06-25 18:08:08.6033 INFO::Creating boxplot for categorical data, diagnosis vs F435
## 2024-06-25 18:08:08.761038 INFO::Creating boxplot for categorical data, diagnosis vs F574
## 2024-06-25 18:08:08.922116 INFO::Creating boxplot for categorical data, diagnosis vs F70
## 2024-06-25 18:08:09.083485 INFO::Creating boxplot for categorical data, diagnosis vs F146
## 2024-06-25 18:08:09.253943 INFO::Creating boxplot for categorical data, diagnosis vs F236
## 2024-06-25 18:08:09.409333 INFO::Creating boxplot for categorical data, diagnosis vs F527
## 2024-06-25 18:08:09.565293 INFO::Creating boxplot for categorical data, diagnosis vs F624
## 2024-06-25 18:08:09.723093 INFO::Creating boxplot for categorical data, diagnosis vs F426
## 2024-06-25 18:08:09.883254 INFO::Creating boxplot for categorical data, diagnosis vs F880
## 2024-06-25 18:08:10.043594 INFO::Creating boxplot for categorical data, diagnosis vs F549
## 2024-06-25 18:08:10.208191 INFO::Creating boxplot for categorical data, diagnosis vs F49
## 2024-06-25 18:08:10.36291 INFO::Creating boxplot for categorical data, diagnosis vs F67
## 2024-06-25 18:08:10.520912 INFO::Creating boxplot for categorical data, diagnosis vs F491
## 2024-06-25 18:08:10.684471 INFO::Creating boxplot for categorical data, diagnosis vs F174
## 2024-06-25 18:08:10.853388 INFO::Creating boxplot for categorical data, diagnosis vs F254
## 2024-06-25 18:08:11.032755 INFO::Creating boxplot for categorical data, diagnosis vs F112
## 2024-06-25 18:08:11.189898 INFO::Creating boxplot for categorical data, diagnosis vs F235
## 2024-06-25 18:08:11.351515 INFO::Creating boxplot for categorical data, diagnosis vs F833
## 2024-06-25 18:08:11.52423 INFO::Creating boxplot for categorical data, diagnosis vs F752
## 2024-06-25 18:08:11.684691 INFO::Creating boxplot for categorical data, diagnosis vs F792
## 2024-06-25 18:08:11.855976 INFO::Creating boxplot for categorical data, diagnosis vs F422
## 2024-06-25 18:08:12.013986 INFO::Creating boxplot for categorical data, diagnosis vs F6
## 2024-06-25 18:08:12.169232 INFO::Creating boxplot for categorical data, diagnosis vs F463
## 2024-06-25 18:08:12.327041 INFO::Creating boxplot for categorical data, diagnosis vs F706
## 2024-06-25 18:08:12.488896 INFO::Creating boxplot for categorical data, diagnosis vs F642
## 2024-06-25 18:08:12.651271 INFO::Creating boxplot for categorical data, diagnosis vs F65
## 2024-06-25 18:08:12.822448 INFO::Creating boxplot for categorical data, diagnosis vs F102
## 2024-06-25 18:08:12.977976 INFO::Creating boxplot for categorical data, diagnosis vs F783
## 2024-06-25 18:08:13.133329 INFO::Creating boxplot for categorical data, diagnosis vs F478
## 2024-06-25 18:08:13.291821 INFO::Creating boxplot for categorical data, diagnosis vs F889
## 2024-06-25 18:08:13.456466 INFO::Creating boxplot for categorical data, diagnosis vs F350
## 2024-06-25 18:08:13.628903 INFO::Creating boxplot for categorical data, diagnosis vs F681
## 2024-06-25 18:08:13.782743 INFO::Creating boxplot for categorical data, diagnosis vs F748
## 2024-06-25 18:08:13.94163 INFO::Creating boxplot for categorical data, diagnosis vs F762
## 2024-06-25 18:08:14.102723 INFO::Creating boxplot for categorical data, diagnosis vs F852
## 2024-06-25 18:08:14.26541 INFO::Creating boxplot for categorical data, diagnosis vs F180
## 2024-06-25 18:08:14.429663 INFO::Creating boxplot for categorical data, diagnosis vs F248
## 2024-06-25 18:08:14.595726 INFO::Creating boxplot for categorical data, diagnosis vs F759
## 2024-06-25 18:08:14.752865 INFO::Creating boxplot for categorical data, diagnosis vs F824
## 2024-06-25 18:08:14.916234 INFO::Creating boxplot for categorical data, diagnosis vs F145
## 2024-06-25 18:08:15.082779 INFO::Creating boxplot for categorical data, diagnosis vs F16
## 2024-06-25 18:08:15.244987 INFO::Creating boxplot for categorical data, diagnosis vs F169
## 2024-06-25 18:08:15.418166 INFO::Creating boxplot for categorical data, diagnosis vs F392
## 2024-06-25 18:08:15.573925 INFO::Creating boxplot for categorical data, diagnosis vs F468
## 2024-06-25 18:08:15.730784 INFO::Creating boxplot for categorical data, diagnosis vs F476
## 2024-06-25 18:08:15.892642 INFO::Creating boxplot for categorical data, diagnosis vs F699
## 2024-06-25 18:08:16.057489 INFO::Creating boxplot for categorical data, diagnosis vs F735
## 2024-06-25 18:08:16.232956 INFO::Creating boxplot for categorical data, diagnosis vs F182
## 2024-06-25 18:08:16.392448 INFO::Creating boxplot for categorical data, diagnosis vs F64
## 2024-06-25 18:08:16.549034 INFO::Creating boxplot for categorical data, diagnosis vs F203
## 2024-06-25 18:08:16.723475 INFO::Creating boxplot for categorical data, diagnosis vs F877
## 2024-06-25 18:08:16.896818 INFO::Creating boxplot for categorical data, diagnosis vs F433
## 2024-06-25 18:08:17.087836 INFO::Creating boxplot for categorical data, diagnosis vs F739
## 2024-06-25 18:08:17.259831 INFO::Creating boxplot for categorical data, diagnosis vs F749
## 2024-06-25 18:08:17.433745 INFO::Creating boxplot for categorical data, diagnosis vs F382
## 2024-06-25 18:08:17.597619 INFO::Creating boxplot for categorical data, diagnosis vs F162
## 2024-06-25 18:08:17.761719 INFO::Creating boxplot for categorical data, diagnosis vs F438
## 2024-06-25 18:08:17.926781 INFO::Creating boxplot for categorical data, diagnosis vs F360
## 2024-06-25 18:08:18.111053 INFO::Creating boxplot for categorical data, diagnosis vs F56
## 2024-06-25 18:08:18.268326 INFO::Creating boxplot for categorical data, diagnosis vs F529
## 2024-06-25 18:08:18.430958 INFO::Creating boxplot for categorical data, diagnosis vs F48
## 2024-06-25 18:08:18.59871 INFO::Creating boxplot for categorical data, diagnosis vs F826
## 2024-06-25 18:08:18.773626 INFO::Creating boxplot for categorical data, diagnosis vs F488
## 2024-06-25 18:08:18.948051 INFO::Creating boxplot for categorical data, diagnosis vs F309
## 2024-06-25 18:08:19.107566 INFO::Creating boxplot for categorical data, diagnosis vs F834
## 2024-06-25 18:08:19.270427 INFO::Creating boxplot for categorical data, diagnosis vs F449
## 2024-06-25 18:08:19.440734 INFO::Creating boxplot for categorical data, diagnosis vs F77
## 2024-06-25 18:08:19.602678 INFO::Creating boxplot for categorical data, diagnosis vs F365
## 2024-06-25 18:08:19.775934 INFO::Creating boxplot for categorical data, diagnosis vs F346
## 2024-06-25 18:08:19.934144 INFO::Creating boxplot for categorical data, diagnosis vs F654
## 2024-06-25 18:08:20.093172 INFO::Creating boxplot for categorical data, diagnosis vs F79
## 2024-06-25 18:08:20.255872 INFO::Creating boxplot for categorical data, diagnosis vs F785
## 2024-06-25 18:08:20.417537 INFO::Creating boxplot for categorical data, diagnosis vs F415
## 2024-06-25 18:08:20.588526 INFO::Creating boxplot for categorical data, diagnosis vs F466
## 2024-06-25 18:08:20.748141 INFO::Creating boxplot for categorical data, diagnosis vs F643
## 2024-06-25 18:08:20.903937 INFO::Creating boxplot for categorical data, diagnosis vs F160
## 2024-06-25 18:08:21.064665 INFO::Creating boxplot for categorical data, diagnosis vs F69
## 2024-06-25 18:08:21.226382 INFO::Creating boxplot for categorical data, diagnosis vs F498
## 2024-06-25 18:08:21.390993 INFO::Creating boxplot for categorical data, diagnosis vs F207
## 2024-06-25 18:08:21.563143 INFO::Creating boxplot for categorical data, diagnosis vs F679
## 2024-06-25 18:08:21.719196 INFO::Creating boxplot for categorical data, diagnosis vs F618
## 2024-06-25 18:08:21.874555 INFO::Creating boxplot for categorical data, diagnosis vs F255
## 2024-06-25 18:08:22.034388 INFO::Creating boxplot for categorical data, diagnosis vs F267
## 2024-06-25 18:08:22.195048 INFO::Creating boxplot for categorical data, diagnosis vs F143
## 2024-06-25 18:08:22.407005 INFO::Creating boxplot for categorical data, diagnosis vs F286
## 2024-06-25 18:08:22.566709 INFO::Creating boxplot for categorical data, diagnosis vs F562
## 2024-06-25 18:08:22.726589 INFO::Creating boxplot for categorical data, diagnosis vs F100
## 2024-06-25 18:08:22.897435 INFO::Creating boxplot for categorical data, diagnosis vs F374
## 2024-06-25 18:08:23.068618 INFO::Creating boxplot for categorical data, diagnosis vs F535
## 2024-06-25 18:08:23.254159 INFO::Creating boxplot for categorical data, diagnosis vs F658
## 2024-06-25 18:08:23.41223 INFO::Creating boxplot for categorical data, diagnosis vs F707
## 2024-06-25 18:08:23.565498 INFO::Creating boxplot for categorical data, diagnosis vs F325
## 2024-06-25 18:08:23.72123 INFO::Creating boxplot for categorical data, diagnosis vs F89
## 2024-06-25 18:08:23.881911 INFO::Creating boxplot for categorical data, diagnosis vs F214
## 2024-06-25 18:08:24.043373 INFO::Creating boxplot for categorical data, diagnosis vs F578
## 2024-06-25 18:08:24.223584 INFO::Creating boxplot for categorical data, diagnosis vs F790
## 2024-06-25 18:08:24.383261 INFO::Creating boxplot for categorical data, diagnosis vs F265
## 2024-06-25 18:08:24.541459 INFO::Creating boxplot for categorical data, diagnosis vs F253
## 2024-06-25 18:08:24.701327 INFO::Creating boxplot for categorical data, diagnosis vs F294
## 2024-06-25 18:08:24.861436 INFO::Creating boxplot for categorical data, diagnosis vs F410
## 2024-06-25 18:08:25.045067 INFO::Creating boxplot for categorical data, diagnosis vs F614
## 2024-06-25 18:08:25.207118 INFO::Creating boxplot for categorical data, diagnosis vs F764
## 2024-06-25 18:08:25.363564 INFO::Creating boxplot for categorical data, diagnosis vs F59
## 2024-06-25 18:08:25.521679 INFO::Creating boxplot for categorical data, diagnosis vs F675
## 2024-06-25 18:08:25.684081 INFO::Creating boxplot for categorical data, diagnosis vs F441
## 2024-06-25 18:08:25.846246 INFO::Creating boxplot for categorical data, diagnosis vs F193
## 2024-06-25 18:08:26.019857 INFO::Creating boxplot for categorical data, diagnosis vs F689
## 2024-06-25 18:08:26.178755 INFO::Creating boxplot for categorical data, diagnosis vs F249
## 2024-06-25 18:08:26.336473 INFO::Creating boxplot for categorical data, diagnosis vs F821
## 2024-06-25 18:08:26.50297 INFO::Creating boxplot for categorical data, diagnosis vs F351
## 2024-06-25 18:08:26.670733 INFO::Creating boxplot for categorical data, diagnosis vs F66
## 2024-06-25 18:08:26.853048 INFO::Creating boxplot for categorical data, diagnosis vs F413
## 2024-06-25 18:08:27.008992 INFO::Creating boxplot for categorical data, diagnosis vs F172
## 2024-06-25 18:08:27.16589 INFO::Creating boxplot for categorical data, diagnosis vs F317
## 2024-06-25 18:08:27.32602 INFO::Creating boxplot for categorical data, diagnosis vs F167
## 2024-06-25 18:08:27.487689 INFO::Creating boxplot for categorical data, diagnosis vs F229
## 2024-06-25 18:08:27.647476 INFO::Creating boxplot for categorical data, diagnosis vs F243
## 2024-06-25 18:08:27.829151 INFO::Creating boxplot for categorical data, diagnosis vs F732
## 2024-06-25 18:08:27.984938 INFO::Creating boxplot for categorical data, diagnosis vs F467
## 2024-06-25 18:08:28.141112 INFO::Creating boxplot for categorical data, diagnosis vs F474
## 2024-06-25 18:08:28.305436 INFO::Creating boxplot for categorical data, diagnosis vs F156
## 2024-06-25 18:08:28.466239 INFO::Creating boxplot for categorical data, diagnosis vs F786
## 2024-06-25 18:08:28.640686 INFO::Creating boxplot for categorical data, diagnosis vs F216
## 2024-06-25 18:08:28.798851 INFO::Creating boxplot for categorical data, diagnosis vs F85
## 2024-06-25 18:08:28.953719 INFO::Creating boxplot for categorical data, diagnosis vs F621
## 2024-06-25 18:08:29.111872 INFO::Creating boxplot for categorical data, diagnosis vs F558
## 2024-06-25 18:08:29.270363 INFO::Creating boxplot for categorical data, diagnosis vs F582
## 2024-06-25 18:08:29.448101 INFO::Creating boxplot for categorical data, diagnosis vs F898
## 2024-06-25 18:08:29.609004 INFO::Creating boxplot for categorical data, diagnosis vs F402
## 2024-06-25 18:08:29.767711 INFO::Creating boxplot for categorical data, diagnosis vs F71
## 2024-06-25 18:08:29.9269 INFO::Creating boxplot for categorical data, diagnosis vs F99
## 2024-06-25 18:08:30.087135 INFO::Creating boxplot for categorical data, diagnosis vs F366
## 2024-06-25 18:08:30.24645 INFO::Creating boxplot for categorical data, diagnosis vs F778
## 2024-06-25 18:08:30.42825 INFO::Creating boxplot for categorical data, diagnosis vs F188
## 2024-06-25 18:08:30.585078 INFO::Creating boxplot for categorical data, diagnosis vs F857
## 2024-06-25 18:08:30.740711 INFO::Creating boxplot for categorical data, diagnosis vs F440
## 2024-06-25 18:08:30.903675 INFO::Creating boxplot for categorical data, diagnosis vs F799
## 2024-06-25 18:08:31.069088 INFO::Creating boxplot for categorical data, diagnosis vs F482
## 2024-06-25 18:08:31.248606 INFO::Creating boxplot for categorical data, diagnosis vs F212
## 2024-06-25 18:08:31.405005 INFO::Creating boxplot for categorical data, diagnosis vs F882
## 2024-06-25 18:08:31.561921 INFO::Creating boxplot for categorical data, diagnosis vs F599
## 2024-06-25 18:08:31.721318 INFO::Creating boxplot for categorical data, diagnosis vs F302
## 2024-06-25 18:08:31.878407 INFO::Creating boxplot for categorical data, diagnosis vs F543
## 2024-06-25 18:08:32.0545 INFO::Creating boxplot for categorical data, diagnosis vs F269
## 2024-06-25 18:08:32.217608 INFO::Creating boxplot for categorical data, diagnosis vs F650
## 2024-06-25 18:08:32.375207 INFO::Creating boxplot for categorical data, diagnosis vs F456
## 2024-06-25 18:08:32.533365 INFO::Creating boxplot for categorical data, diagnosis vs F573
## 2024-06-25 18:08:32.699034 INFO::Creating boxplot for categorical data, diagnosis vs F8
## 2024-06-25 18:08:32.865256 INFO::Creating boxplot for categorical data, diagnosis vs F810
## 2024-06-25 18:08:33.049877 INFO::Creating boxplot for categorical data, diagnosis vs F401
## 2024-06-25 18:08:33.212176 INFO::Creating boxplot for categorical data, diagnosis vs F606
## 2024-06-25 18:08:33.369281 INFO::Creating boxplot for categorical data, diagnosis vs F662
## 2024-06-25 18:08:33.531432 INFO::Creating boxplot for categorical data, diagnosis vs F765
## 2024-06-25 18:08:33.690023 INFO::Creating boxplot for categorical data, diagnosis vs F887
## 2024-06-25 18:08:33.86891 INFO::Creating boxplot for categorical data, diagnosis vs F770
## 2024-06-25 18:08:34.025871 INFO::Creating boxplot for categorical data, diagnosis vs F469
## 2024-06-25 18:08:34.184358 INFO::Creating boxplot for categorical data, diagnosis vs F86
## 2024-06-25 18:0