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This is the development version of vulcan; for the stable release version, see vulcan.

VirtUaL ChIP-Seq data Analysis using Networks

Bioconductor version: Development (3.20)

Vulcan (VirtUaL ChIP-Seq Analysis through Networks) is a package that interrogates gene regulatory networks to infer cofactors significantly enriched in a differential binding signature coming from ChIP-Seq data. In order to do so, our package combines strategies from different BioConductor packages: DESeq for data normalization, ChIPpeakAnno and DiffBind for annotation and definition of ChIP-Seq genomic peaks, csaw to define optimal peak width and viper for applying a regulatory network over a differential binding signature.

Author: Federico M. Giorgi, Andrew N. Holding, Florian Markowetz

Maintainer: Federico M. Giorgi <federico.giorgi at>

Citation (from within R, enter citation("vulcan")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Vulcan: VirtUaL ChIP-Seq Analysis through Networks PDF R Script
Reference Manual PDF


biocViews ChIPSeq, GeneExpression, NetworkEnrichment, Software, SystemsBiology
Version 1.27.0
In Bioconductor since BioC 3.6 (R-3.4) (6.5 years)
License LGPL-3
Depends R (>= 4.0), ChIPpeakAnno, TxDb.Hsapiens.UCSC.hg19.knownGene, zoo, GenomicRanges, S4Vectors, viper, DiffBind, locfit
Imports wordcloud, csaw, gplots, stats, utils, caTools, graphics, DESeq2, Biobase
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Follow Installation instructions to use this package in your R session.

Source Package vulcan_1.27.0.tar.gz
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macOS Binary (x86_64) vulcan_1.27.0.tgz
macOS Binary (arm64) vulcan_1.27.0.tgz
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Source Repository (Developer Access) git clone
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