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This is the development version of Wrench; for the stable release version, see Wrench.

Wrench normalization for sparse count data

Bioconductor version: Development (3.20)

Wrench is a package for normalization sparse genomic count data, like that arising from 16s metagenomic surveys.

Author: Senthil Kumar Muthiah [aut], Hector Corrada Bravo [aut, cre]

Maintainer: Hector Corrada Bravo <hcorrada at>

Citation (from within R, enter citation("Wrench")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

Wrench HTML R Script
Reference Manual PDF


biocViews Normalization, Sequencing, Software
Version 1.23.0
In Bioconductor since BioC 3.8 (R-3.5) (5.5 years)
License Artistic-2.0
Depends R (>= 3.5.0)
Imports limma, matrixStats, locfit, stats, graphics
System Requirements
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Suggests knitr, rmarkdown, metagenomeSeq, DESeq2, edgeR
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Imports Me metagenomeSeq
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Follow Installation instructions to use this package in your R session.

Source Package Wrench_1.23.0.tar.gz
Windows Binary
macOS Binary (x86_64) Wrench_1.23.0.tgz
macOS Binary (arm64) Wrench_1.23.0.tgz
Source Repository git clone
Source Repository (Developer Access) git clone
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