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This is the development version of SCBN; for the stable release version, see SCBN.

A statistical normalization method and differential expression analysis for RNA-seq data between different species

Bioconductor version: Development (3.20)

This package provides a scale based normalization (SCBN) method to identify genes with differential expression between different species. It takes into account the available knowledge of conserved orthologous genes and the hypothesis testing framework to detect differentially expressed orthologous genes. The method on this package are described in the article 'A statistical normalization method and differential expression analysis for RNA-seq data between different species' by Yan Zhou, Jiadi Zhu, Tiejun Tong, Junhui Wang, Bingqing Lin, Jun Zhang (2018, pending publication).

Author: Yan Zhou

Maintainer: Yan Zhou <2160090406 at>

Citation (from within R, enter citation("SCBN")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

SCBN Tutorial HTML R Script
Reference Manual PDF


biocViews DifferentialExpression, GeneExpression, Normalization, Software
Version 1.23.0
In Bioconductor since BioC 3.8 (R-3.5) (5.5 years)
License GPL-2
Depends R (>= 3.5.0)
Imports stats
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Suggests knitr, rmarkdown, BiocStyle, BiocManager
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Source Package SCBN_1.23.0.tar.gz
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