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This is the development version of CNAnorm; for the stable release version, see CNAnorm.

A normalization method for Copy Number Aberration in cancer samples

Bioconductor version: Development (3.20)

Performs ratio, GC content correction and normalization of data obtained using low coverage (one read every 100-10,000 bp) high troughput sequencing. It performs a "discrete" normalization looking for the ploidy of the genome. It will also provide tumour content if at least two ploidy states can be found.

Author: Stefano Berri <sberri at>, Henry M. Wood <H.M.Wood at>, Arief Gusnanto <a.gusnanto at>

Maintainer: Stefano Berri <sberri at>

Citation (from within R, enter citation("CNAnorm")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))

# The following initializes usage of Bioc devel


For older versions of R, please refer to the appropriate Bioconductor release.


To view documentation for the version of this package installed in your system, start R and enter:

CNAnorm.pdf PDF R Script
Reference Manual PDF


biocViews CopyNumberVariation, Coverage, DNASeq, GenomicVariation, Normalization, Sequencing, Software, WholeGenome
Version 1.51.0
In Bioconductor since BioC 2.9 (R-2.14) (12.5 years)
License GPL-2
Depends R (>= 2.10.1), methods
Imports DNAcopy
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Source Package CNAnorm_1.51.0.tar.gz
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macOS Binary (x86_64) CNAnorm_1.51.0.tgz
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