Package: normalize450K
Type: Package
Title: Preprocessing of Illumina Infinium 450K data
Version: 1.41.0
Date: 2016-11-29
Author: Jonathan Alexander Heiss
Maintainer: Jonathan Alexander Heiss <jonathan.heiss@posteo.de>
Description: Precise measurements are important for epigenome-wide
        studies investigating DNA methylation in whole blood samples,
        where effect sizes are expected to be small in magnitude. The
        450K platform is often affected by batch effects and proper
        preprocessing is recommended. This package provides functions
        to read and normalize 450K '.idat' files. The normalization
        corrects for dye bias and biases related to signal intensity
        and methylation of probes using local regression. No adjustment
        for probe type bias is performed to avoid the trade-off of
        precision for accuracy of beta-values.
Depends: R (>= 3.3), Biobase, illuminaio, quadprog
Imports: utils
License: BSD_2_clause + file LICENSE
biocViews: Normalization, DNAMethylation, Microarray, TwoChannel,
        Preprocessing, MethylationArray
NeedsCompilation: no
Config/pak/sysreqs: libssl-dev
Repository: https://bioc.r-universe.dev
Date/Publication: 2026-04-28 12:42:18 UTC
RemoteUrl: https://github.com/bioc/normalize450K
RemoteRef: HEAD
RemoteSha: b3b514ac52a07a43eed5a8fc0ef520ef98e89962
Packaged: 2026-05-30 07:22:59 UTC; root
Built: R 4.6.0; ; 2026-05-30 07:24:14 UTC; windows
