Package: ZygosityPredictor
Type: Package
Title: Package for prediction of zygosity for variants/genes in NGS
        data
Version: 1.11.0
Date: 2025-07-28
Authors@R: c(
  person("Marco", "Rheinnecker", 
    email="marco.rheinnecker@dkfz-heidelberg.de", 
    role = c("aut", "cre"),
    comment=c(ORCID="0009-0009-7181-3977")), 
  person("Marc", "Ruebsam", 
    role = c("aut")),
  person("Daniel", "Huebschmann", 
    role = c("aut")),  
  person("Martina", "Froehlich", 
    role = c("aut")),
  person("Barbara", "Hutter", 
    role = c("aut"))
    )
Imports: GenomicAlignments, GenomicRanges, Rsamtools, IRanges,
        VariantAnnotation, DelayedArray, dplyr, stringr, purrr, tibble,
        methods, knitr, igraph, readr, stats, magrittr, rlang
License: GPL-2
Description: The ZygosityPredictor allows to predict how many copies of
        a gene are affected by small variants. In addition to the basic
        calculations of the affected copy number of a variant, the
        Zygosity-Predictor can integrate the influence of several
        variants on a gene and ultimately make a statement if and how
        many wild-type copies of the gene are left. This information
        proves to be of particular use in the context of translational
        medicine. For example, in cancer genomes, the
        Zygosity-Predictor can address whether unmutated copies of
        tumor-suppressor genes are present. Beyond this, it is possible
        to make this statement for all genes of an organism. The
        Zygosity-Predictor was primarily developed to handle SNVs and
        INDELs (later addressed as small-variants) of somatic and
        germline origin. In order not to overlook severe effects
        outside of the small-variant context, it has been extended with
        the assessment of large scale deletions, which cause losses of
        whole genes or parts of them.
RoxygenNote: 7.2.3
Encoding: UTF-8
biocViews: BiomedicalInformatics, FunctionalPrediction,
        SomaticMutation, GenePrediction
Depends: R (>= 4.3.0)
LazyData: false
Suggests: rmarkdown, testthat, BiocStyle
VignetteBuilder: knitr
Config/pak/sysreqs: libglpk-dev make libbz2-dev libicu-dev liblzma-dev
        libpng-dev libxml2-dev libssl-dev libx11-dev xz-utils
        zlib1g-dev
Repository: https://bioc.r-universe.dev
Date/Publication: 2025-10-29 15:22:08 UTC
RemoteUrl: https://github.com/bioc/ZygosityPredictor
RemoteRef: HEAD
RemoteSha: 21ba67a277246be4002a6f4268b9fa835933c20e
NeedsCompilation: no
Packaged: 2026-01-22 19:02:49 UTC; root
Author: Marco Rheinnecker [aut, cre] (ORCID:
    <https://orcid.org/0009-0009-7181-3977>),
  Marc Ruebsam [aut],
  Daniel Huebschmann [aut],
  Martina Froehlich [aut],
  Barbara Hutter [aut]
Maintainer: Marco Rheinnecker <marco.rheinnecker@dkfz-heidelberg.de>
Built: R 4.6.0; ; 2026-01-22 19:16:33 UTC; unix
