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This package is deprecated. It will probably be removed from Bioconductor. Please refer to the package end-of-life guidelines for more information.

A function set for the Extrapolation Strategy (RMA+) and Extrapolation Averaging (RMA++) methods.

Bioconductor version: Release (3.19)

The package contains functions for pre-processing Affymetrix data using the RMA+ and the RMA++ methods.

Author: Kai-Ming Chang <kaiming at>, Chris Harbron <Chris.Harbron at>, Marie C South <Marie.C.South at>

Maintainer: Kai-Ming Chang <kaiming at>

Citation (from within R, enter citation("RefPlus")):


To install this package, start R (version "4.4") and enter:

if (!require("BiocManager", quietly = TRUE))


For older versions of R, please refer to the appropriate Bioconductor release.


Reference Manual PDF


biocViews Microarray, OneChannel, Preprocessing, Software
Version 1.74.0
In Bioconductor since BioC 2.0 (R-2.5) (17 years)
License GPL (>= 2)
Depends R (>= 2.8.0), Biobase(>= 2.1.0), affy(>= 1.20.0), affyPLM(>= 1.18.0), preprocessCore(>= 1.4.0)
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Follow Installation instructions to use this package in your R session.

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macOS Binary (x86_64) RefPlus_1.74.0.tgz
macOS Binary (arm64) RefPlus_1.74.0.tgz
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